There is converging evidence that environmental cues related to tobacco use are critically involved in tobacco dependence. Dr. Caggiula's laboratory is currently investigating the impact of environmental cues on nicotine (NIC) self-administration (SA) in rats. They have found that NIC enhances responding for other reinforcers (i.e., delivery of an environmental cue). However, one shortcoming of these studies is that delivery of the cue and delivery of NIC depend on the same behavior (i.e., pressing an """"""""active"""""""" lever). Thus, the nature of the interaction between the reinforcers (NIC and cue) is not completely clear. The experiments outlined in the present proposal will begin to examine the nature of the interaction between NIC and the environmental cue using a """"""""two-lever"""""""" paradigm. That is, NIC infusions and cue presentations will be controlled by two distinct operants (i.e., pressing different levers). This technique will provide a more sensitive assay of how NIC reinforces behavior and will expand our understanding of chronic tobacco use. Increasing the sensitivity of NIC SA models will provide useful and readily applicable information for behavioral and pharmacological tobacco cessation programs.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32DA019278-01A1
Application #
6999948
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Babecki, Beth
Project Start
2005-06-01
Project End
2007-05-31
Budget Start
2005-06-01
Budget End
2006-05-31
Support Year
1
Fiscal Year
2005
Total Cost
$43,976
Indirect Cost
Name
University of Pittsburgh
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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Palmatier, Matthew I; Levin, Melissa E; Mays, Kara L et al. (2009) Bupropion and nicotine enhance responding for nondrug reinforcers via dissociable pharmacological mechanisms in rats. Psychopharmacology (Berl) 207:381-90
Palmatier, M I; Coddington, S B; Liu, X et al. (2008) The motivation to obtain nicotine-conditioned reinforcers depends on nicotine dose. Neuropharmacology 55:1425-30
Palmatier, Matthew I; Liu, Xiu; Donny, Eric C et al. (2008) Metabotropic glutamate 5 receptor (mGluR5) antagonists decrease nicotine seeking, but do not affect the reinforcement enhancing effects of nicotine. Neuropsychopharmacology 33:2139-47
Palmatier, Matthew I; Liu, Xiu; Matteson, Gina L et al. (2007) Conditioned reinforcement in rats established with self-administered nicotine and enhanced by noncontingent nicotine. Psychopharmacology (Berl) 195:235-43
Palmatier, Matthew I; Liu, Xiu; Caggiula, Anthony R et al. (2007) The role of nicotinic acetylcholine receptors in the primary reinforcing and reinforcement-enhancing effects of nicotine. Neuropsychopharmacology 32:1098-108
Palmatier, Matthew I; Matteson, Gina L; Black, Jessica J et al. (2007) The reinforcement enhancing effects of nicotine depend on the incentive value of non-drug reinforcers and increase with repeated drug injections. Drug Alcohol Depend 89:52-9
Palmatier, Matthew I; Bevins, Rick A (2007) Facilitation by drug states does not depend on acquired excitatory strength. Behav Brain Res 176:292-301
Palmatier, Matthew I; Evans-Martin, F Fay; Hoffman, Alycia et al. (2006) Dissociating the primary reinforcing and reinforcement-enhancing effects of nicotine using a rat self-administration paradigm with concurrently available drug and environmental reinforcers. Psychopharmacology (Berl) 184:391-400