Sex steroid hormones, such as testosterone (T) and 17beta-estradiol (E2) are well known to regulate both behavior and physiology. Many of these effects require that the steroids act on the brain by finding to their steroid receptor proteins that are distributed throughout the brain. An important unanswered question facing the field of neuroendocrinology concerns how steroid action is coordinated at multiple levels. The vocal control system of songbirds is an excellent model system for such components of this circuit that are important in the motor output of song. These include telencephalic nucleic, brainstem nuclei, and the vocal production organ the syrinx. The telencephalic nuclei exhibit a hierarchal organization of motor controls. It is not known if gonadal hormones must act in all these individual nuclei and/or muscle groups simultaneously to produce the full complement of song and whether steroids have independent effects in these different structures. I will investigate steroid action in the song circuit with the selective administration of steroid receptor antagonists centrally and peripherally.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32DC000423-01A1
Application #
6208474
Study Section
Special Emphasis Panel (ZRG1-IFCN-5 (01))
Program Officer
Sklare, Dan
Project Start
2000-08-01
Project End
Budget Start
2000-08-01
Budget End
2001-07-31
Support Year
1
Fiscal Year
2000
Total Cost
$32,416
Indirect Cost
Name
Johns Hopkins University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218