The project will investigate the role of inhabitation in acoustic processing in the mature and developing brainstem auditory system of the domestic chicken. This stay involves a three-pronged approach that constitute the specific aims: 1) to asses the influence of GABAergic input on both pre and postsynaptic elements in thee nucleus in the nucleus magnocellularis; 2) to asses the relative contribution of the primary excitatory and inhibitory inputs to processing of neurons in the superior olivary nucleus; 3) to describe and investigate influences on the efficacy and temporal characteristics of inhibitory inputs to nucleus magnocellularis and nucleus laminar is during development.
Aim 1 will be addressed in vivo using multibarrel electrodes which allow for the pharmacological analysis of the contribution of various GABA receptor electrodes which allow for the pharmacological analysis of the contribution of various GABA receptor subtypes which are differently expressed in pre and postsynaptic terminals in nucleus magnocellularis.
Aims 2 and 3 will autolysin in vitro preparation that will allow for the experimental segregation of inputs to brainstem nuclei and provide access to the biophysical properties of the neurons. These studies will contribute to a more complete understanding of acoustic processing in vertebrate nervous systems. Furthmore, developmental studies may reveal factors that could play a role in recovery of function in deaf patients. Understanding developmental influences on synaptic properties may contribute to the development of appropriate therapies for patients deprived of acoustic stimulation early in life.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32DC000466-02
Application #
6489519
Study Section
Special Emphasis Panel (ZRG1-IFCN-6 (01))
Program Officer
Sklare, Dan
Project Start
2001-12-04
Project End
Budget Start
2001-12-04
Budget End
2002-12-03
Support Year
2
Fiscal Year
2002
Total Cost
$38,320
Indirect Cost
Name
University of Washington
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Willis, Katie L; Carr, Catherine E (2017) A circuit for detection of interaural time differences in the nucleus laminaris of turtles. J Exp Biol 220:4270-4281
Willis, Katie L (2016) Underwater Hearing in Turtles. Adv Exp Med Biol 875:1229-35
Crowell, Sara C (2016) Measuring In-Air and Underwater Hearing in Seabirds. Adv Exp Med Biol 875:1155-60
Chicoli, A; Bak-Coleman, J; Coombs, S et al. (2015) Rheotaxis performance increases with group size in a coupled phase model with sensory noise: The effects of noise and group size on rheotaxis. Eur Phys J Spec Top 224:3233-3244
Crowell, Sara E; Wells-Berlin, Alicia M; Carr, Catherine E et al. (2015) A comparison of auditory brainstem responses across diving bird species. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 201:803-15
Bloom, S; Williams, A; MacLeod, K M (2014) Heterogeneous calretinin expression in the avian cochlear nucleus angularis. J Assoc Res Otolaryngol 15:603-20
Chicoli, A; Butail, S; Lun, Y et al. (2014) The effects of flow on schooling Devario aequipinnatus: school structure, startle response and information transmission. J Fish Biol 84:1401-21
Song, Jing; Wang, Wenbo; Carr, Catherine E et al. (2013) Vestibular nuclei characterized by calcium-binding protein immunoreactivity and tract tracing in Gekko gecko. Hear Res 296:1-12
Willis, Katie L; Christensen-Dalsgaard, Jakob; Ketten, Darlene R et al. (2013) Middle ear cavity morphology is consistent with an aquatic origin for testudines. PLoS One 8:e54086
Daliri, Ayoub; Prokopenko, Roman A; Max, Ludo (2013) Afferent and efferent aspects of mandibular sensorimotor control in adults who stutter. J Speech Lang Hear Res 56:1774-88

Showing the most recent 10 out of 21 publications