The proposed research is to develop thiol-ene polymers for application as dental restorative materials. The goals of this research are to develop thiol-ene materials that will have superior properties relative to current polymers utilized for dental restorative materials. The research will involve studying the relationship between chemical structure, polymerization kinetics, and material properties, these studies will be conducted with commercially available monomers and also novel thiol and ene monomers synthesized in the Bowman and Stansbury research groups. Thiol-ene based dental composite systems with filler particles will also be studied. Critical areas that will be addressed are volume shrinkage and shrinkage stress as well as the stability of the monomer formulations. The compatibility of monomer formulations with filler particles and the properties of filled systems will be evaluated. Biocompatibility of the new dental restorative materials will also be assessed.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32DE015906-01A2
Application #
6999112
Study Section
NIDCR Special Grants Review Committee (DSR)
Program Officer
Avila, Albert
Project Start
2005-09-01
Project End
2007-08-31
Budget Start
2005-09-01
Budget End
2006-08-31
Support Year
1
Fiscal Year
2005
Total Cost
$49,096
Indirect Cost
Name
University of Colorado at Boulder
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
007431505
City
Boulder
State
CO
Country
United States
Zip Code
80309
Cramer, Neil B; Couch, Charles L; Schreck, Kathleen M et al. (2010) Investigation of thiol-ene and thiol-ene-methacrylate based resins as dental restorative materials. Dent Mater 26:21-8
Cramer, Neil B; Couch, Charles L; Schreck, Kathleen M et al. (2010) Properties of methacrylate-thiol-ene formulations as dental restorative materials. Dent Mater 26:799-806
Kilambi, Harini; Cramer, Neil B; Schneidewind, Lauren H et al. (2009) Evaluation of highly reactive mono-methacrylates as reactive diluents for BisGMA-based dental composites. Dent Mater 25:33-8