Cortisol Effects on Bone Insulin-Like Growth Factor I

Delany, Anne M.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Postdoctoral Individual National Research Service Award (F32)
• Project #: 5F32DK009038-03
• Application #: 2135976
• Study Section: Clinical Trials (CLIN)
• Program Officer: Hyde, James F
• Project Start: 1996-03-01
• Budget Start: 1996-03-01
• Budget End: 1997-02-28
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: St. Francis Hospital and Medical Center
• City: Hartford
• State: CT
• Country: United States
• Zip Code: 06105

Publications

Delany, A M (2001) Measuring transcription of metalloproteinase genes. Nuclear run-off assay vs analysis of hnRNA. Methods Mol Biol 151:321-33

Delany, A M; Canalis, E (1998) Basic fibroblast growth factor destabilizes osteonectin mRNA in osteoblasts. Am J Physiol 274:C734-40

Franchimont, N; Rydziel, S; Delany, A M et al. (1997) Interleukin-6 and its soluble receptor cause a marked induction of collagenase 3 expression in rat osteoblast cultures. J Biol Chem 272:12144-50

Rydziel, S; Delany, A M; Canalis, E (1997) Insulin-like growth factor I inhibits the transcription of collagenase 3 in osteoblast cultures. J Cell Biochem 67:176-83

Delany, A M; Rydziel, S; Canalis, E (1996) Autocrine down-regulation of collagenase-3 in rat bone cell cultures by insulin-like growth factors. Endocrinology 137:4665-70

Delany, A M; Jeffrey, J J; Rydziel, S et al. (1995) Cortisol increases interstitial collagenase expression in osteoblasts by post-transcriptional mechanisms. J Biol Chem 270:26607-12

Delany, A M; Canalis, E (1995) Transcriptional repression of insulin-like growth factor I by glucocorticoids in rat bone cells. Endocrinology 136:4776-81