Abstract

These studies are based on an in vitro model of angiogenesis in which blood vessels grow out of embryonic kidney explants. In this system, angiogenesis is markedly stimulated by phorbol esters when the explants are specifically grown in type I collagen. The goals of this study are: 1. To examine the cell matrix interactions crucial for microvessel outgrowth. 2. To assess how phorbol esters stimulate microvessel outgrowth. The long term goals are to gain insight into the process renal vascularization in general, and to the development of the highly specialized glomerular capillary endothelium in particular.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32DK009575-02
Application #
2545693
Study Section
Pathology A Study Section (PTHA)
Program Officer
Rankin, Tracy L
Project Start
1997-10-01
Project End
Budget Start
1997-10-01
Budget End
1998-06-30
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Antes, L M; Kujubu, D A; Fernandez, P C (1998) Hypokalemia and the pathology of ion transport molecules. Semin Nephrol 18:31-45
Antes, L M; Villar, M M; Decker, S et al. (1998) A serum-free in vitro model of renal microvessel development. Am J Physiol 274:F1150-60