The two major goals of this research proposal are the following: to construct an optimal replication deficient adenoviral expression vector; and to evaluate the delivery of a therapeutic protein from this vector in a preclinical model of renal fibrosis. To this end I will utilize sophisticated molecular biological techniques to optimize the construct that I have made and make novel vectors as well. Protein expression will be evaluated in-vivo. After this evaluation is complete I will utilize this vector therapeutically in both a renal ablation and diabetic model of renal fibrosis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32DK009686-01
Application #
2414760
Study Section
Special Emphasis Panel (ZRG4-GRM (02))
Program Officer
Rankin, Tracy L
Project Start
1998-02-10
Project End
Budget Start
1997-07-01
Budget End
1998-06-30
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215