The 2-yr proposed project is aimed at understanding whether or not energy metabolism is altered in reduced-obese subjects as compared to never-obese control subjects. A major hypothesis of the proposal is that the reduced-obese do not constitute a homogeneous group and that energy metabolism may be altered in some but not all reduced- obese subjects. Using the NWCR, the project will begin by examining determinants of resting metabolic rate in reduced-obese subjects. A foil ow-up study will examine total energy expenditure (using doubly labeled water) in subjects who have maintained short (1-2 year ) versus long (greater than 5 year) weight reduction. Finally, the project will assess fat oxidation in response to dietary manipulation in reduced-obese subjects. No previous studies of energy expenditure in reduced obese subjects have used subjects with who have maintained their weight loss for longer than 5 years. in fact, most previously reduced-obese subjects were studied within 6 months of their weight loss. Substantial weight loss can likely produce perturbation in energy metabolism that may last for long periods of time.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32DK009705-02
Application #
2733948
Study Section
Special Emphasis Panel (ZRG2-GMA-2 (01))
Program Officer
Podskalny, Judith M,
Project Start
1998-07-01
Project End
Budget Start
1998-07-01
Budget End
1999-06-30
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Pediatrics
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
Wyatt, H R; Grunwald, G K; Seagle, H M et al. (1999) Resting energy expenditure in reduced-obese subjects in the National Weight Control Registry. Am J Clin Nutr 69:1189-93