In this proposal, the incorporation of molecular analysis and animal studies will be used to address the regulation of the nuclear orphan receptor Nur77. The primary goal of this proposal is to demonstrate how differential phosphorylation of Nur77 can serve as a central control point between extracellular signaling pathways and Nur77 action, which will be accomplished by the following specific aims: 1. To determine the functional consequences of Nur77 phosphorylation., and 2. To address the role of phosphorylation in the regulation of Nur77 by physiological responses in animals. Experiments will address how modifications of Nur77 by adrenocorticotropin hormone (ACTH) mediate Nur77 transcriptional activity and target gene specificity in addition to examining how modification of Nur77 is regulated by physiological stress responses in rodents.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32DK009786-01A1
Application #
2862805
Study Section
Endocrinology Study Section (END)
Program Officer
Hyde, James F
Project Start
1999-04-01
Project End
Budget Start
1999-04-01
Budget End
2000-03-31
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Illinois at Chicago
Department
Genetics
Type
Schools of Medicine
DUNS #
121911077
City
Chicago
State
IL
Country
United States
Zip Code
60612