Abstract

Our laboratory is interested in the role of endogenous serotonin as it relates to gut transport and motility. We have extensive experience with a rat colon model, and plan to expand our work as follows: 1. We will characterize the release and transport response to endogenous 5-HT released via mucosal stimulation. 2. Based on the information learned using rat colon preparations we will delineate the function of physiologic 5-HT on human jejunum using novel isolated perfused tissue model. 3. Concurrently, we will study the effects of physiologic 5-HT on rat bowel transport and motility using an in situ animal model.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32DK009834-01
Application #
2708045
Study Section
Special Emphasis Panel (ZRG7-SSS-8 (43))
Program Officer
Podskalny, Judith M,
Project Start
1999-02-15
Project End
Budget Start
1998-07-01
Budget End
1999-06-30
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Virginia Commonwealth University
Department
Surgery
Type
Schools of Medicine
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298

  Publications

King, Brian N; Stoner, Michael C; Haque, Sheikh M et al. (2004) A nitrergic secretomotor neurotransmitter in the chloride secretory response to serotonin. Dig Dis Sci 49:196-201
Stoner, M C; Kellum, J M (2001) Both serotonin and a nitric-oxide donor cause chloride secretion in rat colonocytes by stimulating cGMP. Surgery 130:236-41
Stoner, M C; Scherr, A M; Lee, J A et al. (2000) Nitric oxide is a neurotransmitter in the chloride secretory response to serotonin in rat colon. Surgery 128:240-5