The proposal's long-term objective is to understand economy of biological design and capacity matching in series biological pathways. By capacity matching is meant the question of whether successive steps in series (such as the enzymes in a reaction chain) have similar capacities, or whether one of those capacities is instead low and rate-limiting. The proposal's specific primary aim is to utilize the method of total parenteral nutrition (TPN) to test capacity matching between organs that process nutrients in series: the intestine, liver, circulation, and kidneys. A specific secondary aim is to utilize TPN to examine mechanisms of appetite satiation. The experiments utilize a new TPN model that administers an identical nutrient mix either by mouth or by TPN to rats.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32DK010071-02
Application #
6380359
Study Section
Endocrinology Study Section (END)
Program Officer
Podskalny, Judith M,
Project Start
2001-07-01
Project End
Budget Start
2001-07-01
Budget End
2002-06-30
Support Year
2
Fiscal Year
2001
Total Cost
$40,196
Indirect Cost
Name
University of California Los Angeles
Department
Physiology
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Steyermark, Anthony C; Mueller, Pamela J (2002) Cage size affects feeding and energetics of captive rodents. Physiol Biochem Zool 75:209-13
Steyermark, Anthony C; Lam, Mandy M; Diamond, Jared (2002) Quantitative evolutionary design of nutrient processing: glucose. Proc Natl Acad Sci U S A 99:8754-9