Abstract

The zinc-finger hemolymphopoietic-restricted transcription factor, Ikaros, is mutated in some human leukemias. Moreover, genetic deletions of the Ikaros DNA-binding domain were associated with an aggressive T lymphocyte leukemia in mice. Thus, the transcriptional regulation of growth-modulating genes by Ikaros may be an important underlying cause for the development of certain leukemias. Recently, we have collected novel data suggesting that Ikaros transcriptionally regulates the expression of VIP-PACAP receptor 1 (VPAC-1), which has been demonstrated to transmit anti-proliferative signals. Therefore, we propose to investigate the transcriptional regulation of VPAC-1 by Ikaros in T lymphocytes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32DK010107-01
Application #
6207615
Study Section
Special Emphasis Panel (ZRG1-SSS-3 (02))
Program Officer
Bishop, Terry Rogers
Project Start
2000-09-01
Project End
Budget Start
2000-09-01
Budget End
2001-08-31
Support Year
1
Fiscal Year
2000
Total Cost
$37,516
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143