Abstract

Understanding the mechanisms involved in liver development is essential for answering how the liver acquires its physiological function. In addition, understanding the molecular events controlling the development of the embryonic as well as adult liver has the promise of providing a variety of therapeutic tools useful in clinical settings aimed at regulating liver growth and regeneration. This proposal aims at understanding the mechanisms controlling liver development using zebrafish as a model system.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32DK068891-02
Application #
7122331
Study Section
Special Emphasis Panel (ZRG1-F05 (20))
Program Officer
Podskalny, Judith M,
Project Start
2005-08-08
Project End
2008-08-07
Budget Start
2006-08-08
Budget End
2007-08-07
Support Year
2
Fiscal Year
2006
Total Cost
$50,428
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Biochemistry
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Chung, Won-Suk; Shin, Chong Hyun; Stainier, Didier Y R (2008) Bmp2 signaling regulates the hepatic versus pancreatic fate decision. Dev Cell 15:738-48
Shin, Chong Hyun; Chung, Won-Suk; Hong, Sung-Kook et al. (2008) Multiple roles for Med12 in vertebrate endoderm development. Dev Biol 317:467-79
Shin, Donghun; Shin, Chong Hyun; Tucker, Jennifer et al. (2007) Bmp and Fgf signaling are essential for liver specification in zebrafish. Development 134:2041-50