Abstract

End-stage renal disease (ESRD) is increasing in incidence and prevalence every year with African Americans disproportionately affected. Patients with ESRD experience many metabolic abnormalities including abnormal calcium, phosphate, bicarbonate and parathyroid hormone (PTH)levels. African Americans are known to have higher levels of parathyroid hormone than Caucasians. It is unclear whether this elevation is of clinical significance and whether there should be different parathyroid hormone goals for African Americans versus Caucasian patients. Dr. Melamed plans to analyze data from the Choices for Healthy Outcomes in Caring for ESRD (CHOICE), an NIDDK-funded study, to investigate the bone disease parameters in African Americans and Caucasians. She intends to obtain data regarding hospital admissions for hip fractures and cardiovascular morbidity and mortality and investigate associations with PTH levels and vitamin D replacement therapy. In addition, in order to investigate determinants of lower bone mineral density in chronic kidney disease she plans to analyze data on inflammation and acidosis from the Third national Health and Nutrition Examination Survey.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32DK069017-01
Application #
6837759
Study Section
Epidemiology of Chronic Diseases Study Section (ECD)
Program Officer
Rankin, Tracy L
Project Start
2004-07-01
Project End
2006-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
1
Fiscal Year
2004
Total Cost
$59,615
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Melamed, Michal L; Michos, Erin D; Post, Wendy et al. (2008) 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch Intern Med 168:1629-37
Melamed, Michal L; Eustace, Joseph A; Plantinga, Laura C et al. (2008) Third-generation parathyroid hormone assays and all-cause mortality in incident dialysis patients: the CHOICE study. Nephrol Dial Transplant 23:1650-8
Gupta, Rajesh; Plantinga, Laura C; Fink, Nancy E et al. (2007) Statin use and sepsis events [corrected] in patients with chronic kidney disease. JAMA 297:1455-64
Melamed, M L; Eustace, J A; Plantinga, L et al. (2006) Changes in serum calcium, phosphate, and PTH and the risk of death in incident dialysis patients: a longitudinal study. Kidney Int 70:351-7
Powe, Neil R; Melamed, Michal L (2005) Racial disparities in the optimal delivery of chronic kidney disease care. Med Clin North Am 89:475-88