Reductive-Oxygenation of Halothane

Christ, David D.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Environmental Health Sciences (NIEHS)
• Type: Postdoctoral Individual National Research Service Award (F32)
• Project #: 3F32ES005368-02S1
• Application #: 3038049
• Study Section: (BI)
• Project Start: 1987-06-13
• Budget Start: 1987-06-13
• Budget End: 1988-06-12
• Support Year: 2
• Fiscal Year: 1988

Institution

• Name: U.S. National Institutes of Health
• City: Bethesda
• State: MD
• Country: United States
• Zip Code: 20892

Publications

Satoh, H; Martin, B M; Schulick, A H et al. (1989) Human anti-endoplasmic reticulum antibodies in sera of patients with halothane-induced hepatitis are directed against a trifluoroacetylated carboxylesterase. Proc Natl Acad Sci U S A 86:322-6

Kenna, J G; Satoh, H; Christ, D D et al. (1988) Metabolic basis for a drug hypersensitivity: antibodies in sera from patients with halothane hepatitis recognize liver neoantigens that contain the trifluoroacetyl group derived from halothane. J Pharmacol Exp Ther 245:1103-9

Christ, D D; Kenna, J G; Kammerer, W et al. (1988) Enflurane metabolism produces covalently bound liver adducts recognized by antibodies from patients with halothane hepatitis. Anesthesiology 69:833-8

Pohl, L R; Satoh, H; Christ, D D et al. (1988) The immunologic and metabolic basis of drug hypersensitivities. Annu Rev Pharmacol Toxicol 28:367-87

Christ, D D; Satoh, H; Kenna, J G et al. (1988) Potential metabolic basis for enflurane hepatitis and the apparent cross-sensitization between enflurane and halothane. Drug Metab Dispos 16:135-40