Binocularvisionisimportantformanyeverydayactivities,anditsdevelopmentreliesonthecouplingof accuratebinoculareyemovementswithstereoscopicfusion.However,thesemechanismsdonotdevelop properlyin2-5%ofthepopulation,whohavechronicimpairmentsintheformofstrabismusandamblyopia. Evaluatingandtreatingstrabismusisparticularlychallengingduetothelimitedavailabilityofautomated assessmentsorrehabilitationproceduresformovingeyesinmultiplepostures.Ascientificunderstandingof thesensoryandoculomotorimpairmentsinstrabismuswillinformclinicalassessmentandlaythefoundation fornewevidence-basedtherapies.Therefore,thegoalsofthisprojectaretotranslatelaboratory-basedeye trackingprocedurestotheclinicwheretheycanautomaticallyquantifythemagnitudeofstrabismusacross differentgazepostures,andthentorelatethesemeasurementstofunctionalimpairmentsinbinocularvision.A thirdgoalistousethesamemethodologicaltechniquestoexaminewhethersensoryandmotordeficitsin strabismuscanbemanipulatedusinganoveloculomotoradaptationprocedure.
Aim1 willdrawonbothwell-establishedclinicalassessmentmethodsandhigh-speedeyetrackingtoquantify themagnitudeandvariabilityofocularmisalignmentacrossdifferentgazeposturesinobserverswithand withoutstrabismus.Inaddition,patients?binocularvisualdeficitswillbemeasuredatthesameposturesto examinetherelationshipbetweenthemagnitudeofmisalignmentandbinocularvisualfunctionforagivengaze direction.Thisvariationisimportanttocapture,asithasbeenshownthatnormally-sightedobserverswithout strabismusexhibitocularmisalignment,andevenstereoblindness,atcertaingazedirections.
Aim2 willdraw onthetechniquesdevelopedinAim1toevaluatetheperceptualandmotoreffectsofdichopticoculomotor adaptation.Previousworkwithnormally-sightedobservershasshownthateyemovementamplitudescanbe adaptivelyrecalibratedinoppositedirectionsinthetwoeyes,buttheshort-termperceptualconsequencesof thisadaptationhavenotbeeninvestigatedineithernormally-sightedsubjectsorpatientswithstrabismus.The resultsofAim2willprovideinsightsintooculomotorplasticityinpatientswithstrabismus,akeystepin developingnon-invasivetherapies.
Strabismusaffects2-5%ofthepopulationandisassociatedwithasyndromeofvisualdeficits,including impairedstereovisionandthesuppressionofvisualinputfromoneeye.Thisprojectwilluseeyetracking methodstomeasureoculomotorandsensorydeficitsinstrabismusatdifferentgazepostures,andtotest whethertheycanbetransientlycorrectedwithafeedback-basedtrainingprocedure.Anunderstandingof theseimpairmentsandhowtheycanbemanipulatedwillguidethedevelopmentofnewassessmentsand treatmentsforstrabismus.
| Vera-Diaz, Fuensanta A; Bex, Peter J; Ferreira, Adriana et al. (2018) Binocular temporal visual processing in myopia. J Vis 18:17 |
