Structure/Activity Study of Peptidyl Amidating Enzyme

Francisco, Wilson A.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of General Medical Sciences (NIGMS)
• Type: Postdoctoral Individual National Research Service Award (F32)
• Project #: 3F32GM017026-02S1
• Application #: 2610595
• Study Section: Biomedical Sciences Study Section (BIOM)
• Project Start: 1996-06-01
• Budget Start: 1996-06-01
• Budget End: 1998-05-31
• Support Year: 2
• Fiscal Year: 1997

Institution

• Name: University of California Berkeley
• Department: Chemistry
• Type: Schools of Arts and Sciences
• DUNS #: 094878337
• City: Berkeley
• State: CA
• Country: United States
• Zip Code: 94704

Publications

Francisco, Wilson A; Blackburn, Ninian J; Klinman, Judith P (2003) Oxygen and hydrogen isotope effects in an active site tyrosine to phenylalanine mutant of peptidylglycine alpha-hydroxylating monooxygenase: mechanistic implications. Biochemistry 42:1813-9

Francisco, Wilson A; Knapp, Michael J; Blackburn, Ninian J et al. (2002) Hydrogen tunneling in peptidylglycine alpha-hydroxylating monooxygenase. J Am Chem Soc 124:8194-5

Francisco, W A; Merkler, D J; Blackburn, N J et al. (1998) Kinetic mechanism and intrinsic isotope effects for the peptidylglycine alpha-amidating enzyme reaction. Biochemistry 37:8244-52