Prediction of molecular structure and function from sequence information has become increasingly possible with the rapidly growing abundance of sequence data. The most successful prediction methods have been comparative methods, which use alignments of homologous sequences to detect positions in the sequence that evolve in tandem, and are therefore likely to be interacting. I intend to improve the accuracy of these methods by incorporating the phylogenetic relationships among the sequences into these analyses. I will then use these more accurate structural predictions to make better multiple sequence alignments and phylogeny estimates. Finally, I plan to tie structure prediction, sequence alignment, and phylogeny estimation together in an iterative fashion in order to improve all three procedures.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32GM020013-02
Application #
6178905
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Program Officer
Cassatt, James
Project Start
1999-06-01
Project End
Budget Start
2000-06-01
Budget End
2001-05-31
Support Year
2
Fiscal Year
2000
Total Cost
$32,416
Indirect Cost
Name
University of Colorado at Boulder
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
City
Boulder
State
CO
Country
United States
Zip Code
80309