The main goals of this research proposal are (1) the mechanistic analysis of a novel aluminum salen catalyzed asymmetric conjugate addition reaction, (2) expansion of substrate scope and utility of the reaction, (3) development of a general synthetic approach for the important class of pentem antibiotics, and (4) the rational development and screening of new conjugate addition reactions. Considering the plethora of potentially valuable compounds resulting from asymmetric conjugate addition reactions, the attainment of these research objectives is deemed a worthwhile achievement.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32GM020402-02
Application #
6351159
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Program Officer
Ikeda, Richard A
Project Start
2001-02-01
Project End
Budget Start
2001-02-01
Budget End
2001-06-18
Support Year
2
Fiscal Year
2001
Total Cost
$15,992
Indirect Cost
Name
Harvard University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
071723621
City
Cambridge
State
MA
Country
United States
Zip Code
02138