The receptor tyrosine kinase/Ras signal transduction pathway is conserved from humans to Caenorhabditis elegans. Although this pathway has been elucidated from the ligand to the transcription factors in both humans and worms, little is known about the targets and downstream factors responsible for the execution of the Ras pathway. Within C.elegans, the Ras pathway induces the development and morphogenesis of the vulva. Factors nessesary for execution of the Ras pathway will be isolated through a lin-1 suppressor screen. lin-1 is the furthest known downstream effector in the C. elegans Ras pathway. The gene abi-2, which controls one of the first morphogeneic changes in vulval development, will also be analyzed for its regulation by the Ras pathway. Combinations of these experiments will allow me to study the molecular mechanisms that execute vulval morphogenesis following an inductive event and may identify candidate factors responsible for the execution of Ras signaling and for tissue differentiation.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32GM020747-02
Application #
6476365
Study Section
Biological Sciences 2 (BIOL)
Program Officer
Tompkins, Laurie
Project Start
2000-12-01
Project End
Budget Start
2001-12-01
Budget End
2002-11-30
Support Year
2
Fiscal Year
2002
Total Cost
$44,212
Indirect Cost
Name
University of Colorado at Boulder
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
City
Boulder
State
CO
Country
United States
Zip Code
80309