This research proposal outlines studies aimed toward the design and development of an efficient catalytic and enantioselective method towards the synthesis of various members of the pyrrolizidine class of alkaloids. Interest in this class of compounds stems from their potential clinical applications as antiviral and antiretroviral agents. The proposed synthesis highlights a novel approach to the enantioselective construction of the 1-azabicyc1o (3.3.0) octane nucleus of the pyrrolizidine alkaloids; this will be achieved through asymmetric ring-opening/ring-closing metathesis of achiral 7-azabicyclo(2.2.1)hepta-2,5-dienes.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32GM064151-02
Application #
6526248
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Program Officer
Marino, Pamela
Project Start
2002-08-01
Project End
2003-05-31
Budget Start
2002-08-01
Budget End
2003-05-31
Support Year
2
Fiscal Year
2002
Total Cost
$37,760
Indirect Cost
Name
Boston College
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
045896339
City
Chestnut Hill
State
MA
Country
United States
Zip Code
02467