The nuclear envelope (NE) has long been appreciated as a gatekeeper to the genome of eukaryotic cells, restricting genomic access only to those molecules capable of traversing the NE via nuclear pore complexes (NPCs). It is increasingly evident, however, that the NE performs active and essential roles in genomic organization beyond providing simple compartmentalization of DMA. NE-associated complexes are important for maintenance of chromatin structure, gene regulation, and DMA replication. Disruption of the NE structure can lead to disregulation of these processes. This proposal focuses on the role of NE membrane proteins in maintaining the structural integrity provided by the NE, with a particular focus on the role of the transmembrane (TM) and lumenal domains of NE membrane proteins. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32GM077919-02
Application #
7235342
Study Section
Special Emphasis Panel (ZRG1-F05-J (20))
Program Officer
Rodewald, Richard D
Project Start
2006-05-15
Project End
2007-08-31
Budget Start
2007-05-15
Budget End
2007-08-31
Support Year
2
Fiscal Year
2007
Total Cost
$15,879
Indirect Cost
Name
Rockefeller University
Department
Anatomy/Cell Biology
Type
Other Domestic Higher Education
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065
King, Megan C; Drivas, Theodore G; Blobel, Gunter (2008) A network of nuclear envelope membrane proteins linking centromeres to microtubules. Cell 134:427-38