The goal of this proposal is to address the limitations of clinically employed photosensitizing drugs in photodynamic therapy (PDT). Novel two-photon absorbing dendrimer photosensitizers are described that are capable of generating singlet oxygen by irradiation with 780 nm light and could allow PDT for treatment of previously inaccessible subcutaneous tumors. The preparation of photosensitizing dendrimer-polymer hybrids are also described as a means to increase the efficacy of the photosenzitizer. Additional elements of novelty included in this proposal include the incorporation of a """"""""pH safety switch"""""""" into the dendrimer that is governed by photoinduced electron transfer, and the development of new core molecules that should allow for the preparation of a variety of multidomain dendrimers. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32GM078780-02
Application #
7281234
Study Section
Special Emphasis Panel (ZRG1-F14-A (20))
Program Officer
Fabian, Miles
Project Start
2006-08-10
Project End
2009-08-09
Budget Start
2007-08-10
Budget End
2008-08-09
Support Year
2
Fiscal Year
2007
Total Cost
$45,976
Indirect Cost
Name
University of California Berkeley
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Pastine, Stefan J; Okawa, David; Zettl, Alex et al. (2009) Chemicals on demand with phototriggerable microcapsules. J Am Chem Soc 131:13586-7
Okawa, David; Pastine, Stefan J; Zettl, Alex et al. (2009) Surface tension mediated conversion of light to work. J Am Chem Soc 131:5396-8