The objective of this proposal is to investigate the possible role of coregulators in gene expression regulated by progesterone receptor and thyroid hormone receptor. Steroid hormones and thyroid hormones are important for growth, cell differentiation, and development in vertebrates. Hormone responses are initiated by the binding of hormone to its nuclear receptor. Subsequently, nuclear receptors (TR, PR) function as transcription factors to regulate the expressions of specific genes by direct or indirect (via coregulators) interactions with the transcriptional machinery at promoters. It has been shown that coregulators are involved in multiple signaling pathway, and participate in nuclear receptor actions within the cell.
The aims of this proposal are to isolate coregulator-associated proteins, to characterize these associated proteins, as well as to study the in-vivo functions of coregulators and their associated proteins. This study will address the following questions: What are the other cellular proteins that associate with coregulators? What is the possible role of these associated factors in the function of coregulators? This study will help us better understand the functions of coregulators and eventually, the mechanism of steroid hormone action.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32HD008445-02
Application #
2888812
Study Section
Special Emphasis Panel (ZRG2-REB (01))
Program Officer
Vogel, Donna L
Project Start
1999-08-01
Project End
Budget Start
1999-08-01
Budget End
2000-07-31
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030