The broad, long-term objective of this research proposal is to understand the origin of specificity in protein-DNA interactions. Specifically, the research outlined in this proposal involves thermodynamically characterizing E. coil tryptophan repressor protein-DNA interactions and examining the role of water in these binding events. Ultimately, the results of this research will contribute to the information base regarding transcriptional regulation, which will assist in the understanding and treatment of disease states involving transcriptional regulation.

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32HG000178-02
Application #
2546131
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Project Start
1997-10-01
Project End
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
Schools of Pharmacy
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715