Elastin Regulation in Lung Development and Disease

Mariani, Thomas J.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Postdoctoral Individual National Research Service Award (F32)
• Project #: 5F32HL009179-03
• Application #: 2027644
• Study Section: Clinical Trials (CLIN)
• Project Start: 1996-12-01
• Budget Start: 1996-12-01
• Budget End: 1997-11-30
• Support Year: 3
• Fiscal Year: 1997

Institution

• Name: Barnes-Jewish Hospital
• City: Saint Louis
• State: MO
• Country: United States
• Zip Code: 63110

Publications

Mariani, T J; Arikan, M C; Pierce, R A (1999) Fibroblast tropoelastin and alpha-smooth-muscle actin expression are repressed by particulate-activated macrophage-derived tumor necrosis factor-alpha in experimental silicosis. Am J Respir Cell Mol Biol 21:185-92

Mariani, T J; Dunsmore, S E; Li, Q et al. (1998) Regulation of lung fibroblast tropoelastin expression by alveolar epithelial cells. Am J Physiol 274:L47-57

Mariani, T J; Sandefur, S; Roby, J D et al. (1998) Collagenase-3 induction in rat lung fibroblasts requires the combined effects of tumor necrosis factor-alpha and 12-lipoxygenase metabolites: a model of macrophage-induced, fibroblast-driven extracellular matrix remodeling during inflammatory lung injury. Mol Biol Cell 9:1411-24