The objective of this proposal is to more fully understand the roles of chemokines and scavenger receptors in atherogenesis. Chemokines and scavenger receptors mediate processes crucial to the early formation of the atherosclerotic lesion. CXCL16, a recently identified chemokine that mediates the chemotaxis of activated T cells, also binds and internalizes oxidized low density lipoproteins (OxLDL). CXCL16 exists as a membrane-bound protein similar in structure to the chemokine fractalkine, in vitro assays will be used to define the OxLDL binding domains of CXCL16, and compare this activity to fractalkine. Also, the progression of atherosclerosis will be measured in CXCL16 knockout mice. This data will determine if CXCL16 is a critical factor in atherogenesis in vivo, providing important insights into the roles of chemokines and scavenger receptors in this disease model.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32HL074514-02
Application #
6793204
Study Section
Special Emphasis Panel (ZRG1-F10 (20))
Program Officer
Schucker, Beth
Project Start
2003-08-15
Project End
2006-08-14
Budget Start
2004-08-15
Budget End
2005-08-14
Support Year
2
Fiscal Year
2004
Total Cost
$48,928
Indirect Cost
Name
J. David Gladstone Institutes
Department
Type
DUNS #
099992430
City
San Francisco
State
CA
Country
United States
Zip Code
94158