The prevalence of asthma in certain Hispanic subgroups in the U.S. and Latin America is among the highestin the world. The goals of this research proposal are to train the applicant in the genetic epidemiology ofcomplex respiratory diseases and to test for association between variants in positional candidate genes andasthma and its related phenotypes in an isolated Hispanic population in the Central Valley of Costa Rica.First, as a specific aim, this grant will train the applicant in the genetic epidemiology of a complex pulmonarydisease through the attainment of a master'sdegree in public health and formal research training. Second,as a specific aim, the applicant will genotype single nucleotide polymorphisms (SNPs) in five candidategenes in a genomic region linked to asthma and/or its related phenotypes in families of children with asthmain Costa Rica. Finally, as a specific aim, the applicant will perform a family-based analysis of associationbetween SNPs and haplotypes in selected candidate genes and asthma and its related phenotypes.
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| Tremblay, Karine; Lemire, Mathieu; Potvin, Camille et al. (2008) Genes to diseases (G2D) computational method to identify asthma candidate genes. PLoS One 3:e2907 |
| Ly, Ngoc P; Soto-Quiros, Manuel E; Avila, Lydiana et al. (2008) Paternal asthma, mold exposure, and increased airway responsiveness among children with asthma in Costa Rica. Chest 133:107-14 |
| Pistiner, Michael; Hunninghake, Gary M; Soto-Quiros, Manuel E et al. (2008) Polymorphisms in IL12A and cockroach allergy in children with asthma. Clin Mol Allergy 6:6 |
| Hunninghake, Gary M; Lasky-Su, Jessica; Soto-Quiros, Manuel E et al. (2008) Sex-stratified linkage analysis identifies a female-specific locus for IgE to cockroach in Costa Ricans. Am J Respir Crit Care Med 177:830-6 |
| Hunninghake, Gary M; Soto-Quiros, Manuel E; Avila, Lydiana et al. (2007) Polymorphisms in IL13, total IgE, eosinophilia, and asthma exacerbations in childhood. J Allergy Clin Immunol 120:84-90 |
| Hunninghake, Gary M; Soto-Quiros, Manuel E; Avila, Lydiana et al. (2007) Sensitization to Ascaris lumbricoides and severity of childhood asthma in Costa Rica. J Allergy Clin Immunol 119:654-61 |
