?s abstract): A critical but under-represented area of research in cognitive psychology and cognitive neuroscience concerns mechanisms responsible for adaptive regulation of cognitive control. One recent computational model that addresses this neglected subject holds that the mesencephalic dopamine system conveys reinforcement learning signals to motor areas in anterior cingulate cortex, where they are used to improve performance on the task at hand. According to the model, the transfer of negative reinforcement learning signals to anterior cingulate cortex elicits the """"""""Error-related Negativity,"""""""" an event- related brain potential (ERP) observed when human subjects commit errors in psychological reaction-time tasks. The goal now is to explore and extend this account by testing it against a competing theory of the ERN, by testing several additional predictions of the model, and by integrating it with an existing model of the mesencephalic dopamine system. The proposed studies consist of two combined functional magnetic resonance imaging/ERP experiments, two additional ERP experiments, and a computational modeling project. This research is expected to elucidate the nature of several clinical disorders associated with impairments of executive control, including schizophrenia, Huntington?s disease, obsessive-compulsive disorder, and frontal damage.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32MH063550-02
Application #
6539263
Study Section
Special Emphasis Panel (ZRG1-IFCN-7 (01))
Program Officer
Curvey, Mary F
Project Start
2002-07-01
Project End
Budget Start
2002-07-01
Budget End
2003-06-30
Support Year
2
Fiscal Year
2002
Total Cost
$38,320
Indirect Cost
Name
Princeton University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
002484665
City
Princeton
State
NJ
Country
United States
Zip Code
08544
Holroyd, Clay B; Coles, Michael G H (2008) Dorsal anterior cingulate cortex integrates reinforcement history to guide voluntary behavior. Cortex 44:548-59
Holroyd, Clay B; Hajcak, Greg; Larsen, Jeff T (2006) The good, the bad and the neutral: electrophysiological responses to feedback stimuli. Brain Res 1105:93-101
Hajcak, Greg; Holroyd, Clay B; Moser, Jason S et al. (2005) Brain potentials associated with expected and unexpected good and bad outcomes. Psychophysiology 42:161-70
Holroyd, Clay B; Yeung, Nick; Coles, Michael G H et al. (2005) A mechanism for error detection in speeded response time tasks. J Exp Psychol Gen 134:163-91
Yeung, Nick; Holroyd, Clay B; Cohen, Jonathan D (2005) ERP correlates of feedback and reward processing in the presence and absence of response choice. Cereb Cortex 15:535-44
Holroyd, Clay B; Larsen, Jeff T; Cohen, Jonathan D (2004) Context dependence of the event-related brain potential associated with reward and punishment. Psychophysiology 41:245-53
Nieuwenhuis, Sander; Yeung, Nick; Holroyd, Clay B et al. (2004) Sensitivity of electrophysiological activity from medial frontal cortex to utilitarian and performance feedback. Cereb Cortex 14:741-7
Holroyd, Clay B; Nieuwenhuis, Sander; Yeung, Nick et al. (2004) Dorsal anterior cingulate cortex shows fMRI response to internal and external error signals. Nat Neurosci 7:497-8
Yeung, Nick; Bogacz, Rafal; Holroyd, Clay B et al. (2004) Detection of synchronized oscillations in the electroencephalogram: an evaluation of methods. Psychophysiology 41:822-32
Holroyd, Clay B; Nieuwenhuis, Sander; Yeung, Nick et al. (2003) Errors in reward prediction are reflected in the event-related brain potential. Neuroreport 14:2481-4