Vesicle trafficking of neurotransmitters, neuronal response to nitric oxide, and SOCaE are critical functions in neurons. The InsP3-R may be a crucial regulator of these processes (see sec 30b). Binding partners of the InsP3-R that we identify may modulate such regulation. Recent work in this field has demonstrated that the InsP3-R is a central entity in many Ca2+ signaling pathways in neuronal systems. Identification of the microenvironment of proteins in which the InsP3-R resides will further our knowledge of InsP3-R, and its binding partners involvement within in neuronal signaling pathways. Additionally it will increase our knowledge of how the InsP3-R is able to discriminate between the many pathways that converge on its activity. The main objective of this proposal is to examine the role of the InsP3-R and InsP3-R signaling pathways in neurons. Specifically I intend to identify binding partners for the InsP3-R, and examine their roles in neurotransmitter secretion, SOCaE, and regulation of the InsP3-R itself.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32MH065090-01
Application #
6446438
Study Section
Special Emphasis Panel (ZRG1-MDCN-1 (01))
Program Officer
Goldschmidts, Walter L
Project Start
2002-09-16
Project End
Budget Start
2002-09-16
Budget End
2003-09-15
Support Year
1
Fiscal Year
2001
Total Cost
$33,260
Indirect Cost
Name
Johns Hopkins University
Department
Neurosciences
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218