Abstract

The broad goal of this project is to help understand mechanisms for synaptic plasticity. One mechanism for long-term potentiation (LTP) or long-term depression (LTD) requires AMPA receptors recycling regulated by activation of protein phosphorylation downstream of the NMDA receptor. However, the specific cellular mechanisms that regulate AMPA receptors trafficking by synaptic activity remain largely unclear. To address this important problem, I have configured a biochemical strategy to characterize the machinery responsible for AMPA receptor trafficking by phosphorylation of stargazin, which is essential for functional AMPA receptors and is highly phosphorylated in brain. Due to the interdependence of the regulation of functional AMPA receptor by stargazin and the function of stargazin phosphorylation, this work has broad implications for mechanisms of learning and memory. ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32MH066469-02
Application #
6837064
Study Section
Special Emphasis Panel (ZRG1-F03A (20))
Program Officer
Curvey, Mary F
Project Start
2003-07-01
Project End
2005-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
2
Fiscal Year
2004
Total Cost
$50,548
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Physiology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Gotham, Katherine; Unruh, Kathryn; Lord, Catherine (2015) Depression and its measurement in verbal adolescents and adults with autism spectrum disorder. Autism 19:491-504
Gotham, Katherine; Brunwasser, Steven M; Lord, Catherine (2015) Depressive and anxiety symptom trajectories from school age through young adulthood in samples with autism spectrum disorder and developmental delay. J Am Acad Child Adolesc Psychiatry 54:369-76.e3
Kim, So Hyun; Thurm, Audrey; Shumway, Stacy et al. (2013) Multisite study of new autism diagnostic interview-revised (ADI-R) algorithms for toddlers and young preschoolers. J Autism Dev Disord 43:1527-38
Charman, Tony; Gotham, Katherine (2013) Measurement Issues: Screening and diagnostic instruments for autism spectrum disorders - lessons from research and practice. Child Adolesc Ment Health 18:52-63
Kim, So Hyun; Lord, Catherine (2012) Combining information from multiple sources for the diagnosis of autism spectrum disorders for toddlers and young preschoolers from 12 to 47 months of age. J Child Psychol Psychiatry 53:143-51
Gotham, Katherine; Pickles, Andrew; Lord, Catherine (2012) Trajectories of autism severity in children using standardized ADOS scores. Pediatrics 130:e1278-84
Luyster, Rhiannon; Lord, Catherine (2009) Word learning in children with autism spectrum disorders. Dev Psychol 45:1774-86
Klein-Tasman, Bonita P; Phillips, Kristin D; Lord, Catherine et al. (2009) Overlap with the autism spectrum in young children with Williams syndrome. J Dev Behav Pediatr 30:289-99
Luyster, Rhiannon; Gotham, Katherine; Guthrie, Whitney et al. (2009) The Autism Diagnostic Observation Schedule-toddler module: a new module of a standardized diagnostic measure for autism spectrum disorders. J Autism Dev Disord 39:1305-20
Gotham, Katherine; Pickles, Andrew; Lord, Catherine (2009) Standardizing ADOS scores for a measure of severity in autism spectrum disorders. J Autism Dev Disord 39:693-705

Showing the most recent 10 out of 15 publications