Abstract

Her focus is on the mechanism by which exogenous gangliosides enhance neuritogenesis. Using clonal neuroblastic cell lines, she will explore whether there is a relationship between ganglioside- induced neuritogenesis and expression of NCAM isoforms. To explore the role of the oligosaccharide portion of the ganglioside on neuritogenesis, she will isolate the oligosaccharide portion and link several together to form dendrimers. Then, she will turn to 2 models of peripheral nerve regeneration (crush and botulinus) to see if muscle reinnervation is accompanied by changes in NCAM isoforms.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32NS010600-02
Application #
2796999
Study Section
Special Emphasis Panel (ZRG1-NLS-3 (02))
Program Officer
Chiu, Arlene Y
Project Start
1998-09-22
Project End
Budget Start
1998-09-22
Budget End
1999-09-21
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Pennsylvania State University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033