This research proposal is directed toward an understanding of how the neuregulins (NRGs) affect the proliferation and differentiation of olidendroglial progenitors, their lineages and Schwann cells. The first described neuregulin, NRG-1, is a potent Schwann cell mitogen and appears to have similar effects on oligodendroglial precursors. The ErbB subfamily of receptor protein-tyrosine kinases transduce neuregulin signals. This application proposes to test the hypothesis that the recently identified neuregulin-like molecule, NRG-2, also shares these activities. Specifically, first the sites of NRG-2 will be characterized in the developing rat nervous system in aim 1.
In aim 2, the ability of NRG-2 to promote oligodendroglial precursor and schwann cell proliferation will be assessed. Lastly, in aim 3, the specific ErbB receptors activated in these cells will be determined. Through these efforts, we hope to improve our understanding of whether NRG-1 and NRG-2 serve similar or distinct roles in the mammalian nervous system.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32NS010970-03
Application #
6402832
Study Section
Special Emphasis Panel (ZRG1-MDCN-2 (01))
Program Officer
Behar, Toby
Project Start
2001-09-16
Project End
Budget Start
2001-09-16
Budget End
2002-05-03
Support Year
3
Fiscal Year
2001
Total Cost
$33,127
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037