Neurons have structurally and functionally distinct processes, the axon and the dendrite. The segregation of proteins into these compartments is essential for the normal functioning of the neuron. Despite the fundamental importance of this process, little is known about how neurons become polarized. This proposal seeks to investigate this process using C. elegans genetics. Both molecular and phenotype-driven analyses will be undertaken. For the former, candidate genes will be tested for their role in neuronal polarity. For the latter, a genetic screen will be undertaken to identify novel components of this process. In addition to providing insight into neuronal polarity in particular, these experiments could lead to a greater understanding of how cells become polarized in general. Thus this work could have implications far beyond the scope of neurobiology, into areas such as cancer research and immunology.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32NS043843-02
Application #
6626174
Study Section
Special Emphasis Panel (ZRG1-F03A (20))
Program Officer
Mamounas, Laura
Project Start
2002-05-01
Project End
Budget Start
2003-05-01
Budget End
2003-06-30
Support Year
2
Fiscal Year
2003
Total Cost
$9,202
Indirect Cost
Name
University of California San Francisco
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143