The goal of this proposal is to correlate the hemodynamic BOLD signal with cellular electrophysiological activity in the human medial temporal lobes. This project proposes to perform high-resolution structural imaging studies of the hippocampal area during performance of navigation tasks. Using computational methods that allow unfolding of activity in subregions of the brain, I will examine fMRI BOLD activity in the subnuclei of the hippocampus and specific layers of the parahippoccampal region. These same patients will subsequently be implanted with depth electrodes in these brain regions as part of resection planning for treatment of pharmacologically intractable epilepsy. Using an 128 channel recording system that allows continuous sampling of wide band electrophysiological data, both EEG and single neuron responses in the hippocampal area will be examined. By examining EEG and single neuron responses to behaviorally relevant events, these signals will then be correlated with the BOLD signal. Testing with control subjects will provide insight into which activations in patients may represent impairments due to seizures and can justify comparing our findings on correlations between BOLD and electrophysiology to normal brain activity. ? ?
| Suthana, Nanthia A; Parikshak, Neelroop N; Ekstrom, Arne D et al. (2015) Specific responses of human hippocampal neurons are associated with better memory. Proc Natl Acad Sci U S A 112:10503-8 |
| Suthana, Nanthia; Ekstrom, Arne; Moshirvaziri, Saba et al. (2011) Dissociations within human hippocampal subregions during encoding and retrieval of spatial information. Hippocampus 21:694-701 |
| Jacobs, Joshua; Korolev, Igor O; Caplan, Jeremy B et al. (2010) Right-lateralized brain oscillations in human spatial navigation. J Cogn Neurosci 22:824-36 |
| Jacobs, Joshua; Kahana, Michael J; Ekstrom, Arne D et al. (2010) A sense of direction in human entorhinal cortex. Proc Natl Acad Sci U S A 107:6487-92 |
| Jacobs, Joshua; Kahana, Michael J (2010) Direct brain recordings fuel advances in cognitive electrophysiology. Trends Cogn Sci 14:162-71 |
| Ekstrom, Arne (2010) How and when the fMRI BOLD signal relates to underlying neural activity: the danger in dissociation. Brain Res Rev 62:233-44 |
| Suthana, Nanthia A; Ekstrom, Arne D; Moshirvaziri, Saba et al. (2009) Human hippocampal CA1 involvement during allocentric encoding of spatial information. J Neurosci 29:10512-9 |
| Ekstrom, Arne D; Bazih, Adam J; Suthana, Nanthia A et al. (2009) Advances in high-resolution imaging and computational unfolding of the human hippocampus. Neuroimage 47:42-9 |
| Manning, Jeremy R; Jacobs, Joshua; Fried, Itzhak et al. (2009) Broadband shifts in local field potential power spectra are correlated with single-neuron spiking in humans. J Neurosci 29:13613-20 |
| Ekstrom, Arne; Suthana, Nanthia; Millett, David et al. (2009) Correlation between BOLD fMRI and theta-band local field potentials in the human hippocampal area. J Neurophysiol 101:2668-78 |
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