The proposed research investigates areas of the brain that adapt in order to associate actions with temporal sound patterns. The development of action-sound associations is essential for behaviorally relevant sound mappings, including production and perception of speech and music. Neural plasticity will be compared across groups with and without lesions (both real and rTMS induced """"""""virtual"""""""" lesions) to left ventral prefrontal cortex (PFCv) to examine short and long-term plasticity in brain regions associated with language recovery from Broca's aphasia. Three proposed experiments, using complimentary research techniques - fMRI and rTMS, test hypotheses concerning a learned somatotopic mapping in premotor cortex for processing meaningful temporal structures, and the effect of re-mapping action to non-verbal sound on clinical language recovery. Neuroimaging measurements will be collected from participants as they discriminate between sequences of sine tones before and after training new associations between hand movements and the sound patterns. Findings will be relevant to the development of recovery methods for victims of stroke and to fundamental issues in brain adaptation for sensory-action pairings.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32NS053326-02
Application #
7120478
Study Section
Special Emphasis Panel (ZRG1-F12A (20))
Program Officer
Chen, Daofen
Project Start
2005-09-30
Project End
2007-01-02
Budget Start
2006-09-30
Budget End
2007-01-02
Support Year
2
Fiscal Year
2006
Total Cost
$8,430
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02215
Vines, Bradley W; Norton, Andrea C; Schlaug, Gottfried (2011) Non-invasive brain stimulation enhances the effects of melodic intonation therapy. Front Psychol 2:230
Järvinen-Pasley, Anna; Vines, Bradley W; Hill, Kiley J et al. (2010) Cross-modal influences of affect across social and non-social domains in individuals with Williams syndrome. Neuropsychologia 48:456-66
Vines, Bradley W; Cerruti, Carlo; Schlaug, Gottfried (2008) Dual-hemisphere tDCS facilitates greater improvements for healthy subjects'non-dominant hand compared to uni-hemisphere stimulation. BMC Neurosci 9:103
Vines, Bradley W; Nair, Dinesh; Schlaug, Gottfried (2008) Modulating activity in the motor cortex affects performance for the two hands differently depending upon which hemisphere is stimulated. Eur J Neurosci 28:1667-73
Vines, Bradley W; Schnider, Nora M; Schlaug, Gottfried (2006) Testing for causality with transcranial direct current stimulation: pitch memory and the left supramarginal gyrus. Neuroreport 17:1047-50
Vines, Bradley W; Nair, Dinesh G; Schlaug, Gottfried (2006) Contralateral and ipsilateral motor effects after transcranial direct current stimulation. Neuroreport 17:671-4