The proposed research will explore the use of spectral and coherence information in biomedical optical imaging for identifying biological tissue properties. Two novel optical systems are proposed for collecting spectral and coherence information about light scattered from biological samples. The optical systems will be used to examine the light scattered from suspensions of cells, suspensions of cell organelles, and cell monolayers to discern what medically relevant information can be obtained. The proposed studies will serve as a basis for developing models of light scattering by biological tissues.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32RR005075-03
Application #
6540573
Study Section
Diagnostic Radiology Study Section (RNM)
Program Officer
Farber, Gregory K
Project Start
2002-04-01
Project End
Budget Start
2002-04-01
Budget End
2002-08-31
Support Year
3
Fiscal Year
2002
Total Cost
$44,212
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Internal Medicine/Medicine
Type
Schools of Arts and Sciences
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Wax, Adam; Yang, Changhuei; Muller, Markus G et al. (2003) In situ detection of neoplastic transformation and chemopreventive effects in rat esophagus epithelium using angle-resolved low-coherence interferometry. Cancer Res 63:3556-9
Wax, Adam; Yang, Changhuei; Backman, Vadim et al. (2002) Cellular organization and substructure measured using angle-resolved low-coherence interferometry. Biophys J 82:2256-64
Wax, Adam; Yang, Changhuei; Backman, Vadim et al. (2002) Determination of particle size by using the angular distribution of backscattered light as measured with low-coherence interferometry. J Opt Soc Am A Opt Image Sci Vis 19:737-44