Abstract

: To develop and use an animal model for studying immune responses to antigen expressed in healthy and neoplastic intestine, addressing: 1) The role of thymus in tolerance of gut specific antigens and the generation of regulatory T cells (Treg), 2) The role of encounter of antigen in the periphery on the maturation and survival of Treg, 3) The immunologic consequences of delayed as compared with constitutive gut specific expression of antigen, 4) The influence of tumor growth on immune responses and tolerance.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
National Research Service Awards for Senior Fellows (F33)
Project #
5F33CA097728-02
Application #
6645334
Study Section
Special Emphasis Panel (ZRG1-F07 (20))
Program Officer
Lohrey, Nancy
Project Start
2002-08-12
Project End
2004-08-11
Budget Start
2003-08-12
Budget End
2004-08-11
Support Year
2
Fiscal Year
2003
Total Cost
$56,308
Indirect Cost

  Institution

Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
076580745
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Dennis, Kristen L; Wang, Yunwei; Blatner, Nichole R et al. (2013) Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells. Cancer Res 73:5905-13
Chen, Mei-Ling; Pittet, Mikael J; Gorelik, Leonid et al. (2005) Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc Natl Acad Sci U S A 102:419-24