The project consists of the integration of existing models and experimental data into a comprehensive hierarchical model of the stringent response. To achieve this we will organize a database-driven repository of relevant parameters and experimental data. This repository will also include the relevant models, theories and published calculations. One purpose of this project is to maximize the benefit of existing data by disseminating it and by facilitating the building and improvement of comprehensive models. The project will also enhance feedback between modeling and experiment by helping identify problems with existing data and areas where more data is required. A framework will be developed to provide a concise and meaningful categorization of models. Attention will be given to the underlying datasets, cross-reference with data sources and data cleanup procedures. Data will be categorized by its nature, source, experimental method, uncertainty, relevance to specific research problem. Parameters and experimental results will be cross-referenced with model calculations.

Agency
National Institute of Health (NIH)
Institute
National Library of Medicine (NLM)
Type
Medical Informatics Fellowships (F37)
Project #
5F37LM008343-02
Application #
6933844
Study Section
Biomedical Library and Informatics Review Committee (BLR)
Program Officer
Florance, Valerie
Project Start
2004-09-01
Project End
2006-08-31
Budget Start
2005-09-01
Budget End
2006-08-31
Support Year
2
Fiscal Year
2005
Total Cost
$62,959
Indirect Cost
Name
University of Pennsylvania
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Halasz, A; Kumar, V; Imielinski, M et al. (2007) Analysis of lactose metabolism in E. Coli using reachability analysis of hybrid systems. IET Syst Biol 1:130-48