Mild cognitive impairment (MCI) is an important condition; 10-15% of MCI subjects convert to Alzheimer's disease (AD) per year, compared to 1-2% in the general population. The long-term goal of this candidate is to develop an independent program dedicated to the prevention of AD through the investigation of risk factors for MCI. To achieve this, the candidate needs expertise and knowledge in neurodegenerative diseases, and longitudinal population-based research in MCI and AD. The candidate is applying for this K01 Mentored Research Scientist Development Award to facilitate a transition from the study of prostatic diseases to the study of neurodegenerative diseases. The K01 award will meet the long-term goal of the candidate through two short term goals: 1) To develop understanding and expertise in neurodegenerative disorders, with an emphasis on MCI, an intermediate stage between normal aging and AD; and 2) To develop expertise in identification of vascular and infammatory risk factors for MCI in a population based longitudinal cohort. These short-term goals will be accomplished through mentored activities, course work, and research. The primary mentor of this candidate, Dr. Ronald Petersen, the Principal Investigator (PI) of the population-based prospective study of MCI, and PI on a recently concluded multi-center clinical trial for MCI, will meet regularly with the candidate to discuss issues regarding characterization of MCI subjects, progress of the study, and novel research regarding MCI. In addition, the candidate will meet with secondary ? mentors in cardiovascular disease Dr Veronique Roger, an eminent cardiologist and epidemiologist with ? special interests in association of dementia and myocardial infarction; and Dr Robert Ivnik, a ? neuropsychologist with extensive experience in the development of population-based age- and educationadjusted neuropsychometric normative data for Olmsted County residents. The candidate's research plan will focus on vascular risk factors and inflammatory markers for MCI. The candidate's research plan is innovative because of the focus on non-cognitive, modifiable risk factors. While genetic risk factors may be important predictors of early onset AD, vascular risk factors may account for a larger proportion of AD. Since they are modifiable, they are more amenable to interventions that may prevent or reduce the risk of MCI and consequently, of AD. In this award, the candidate proposes to investigate hypotheses that vascular risk factors (e.g diabetes, hypertension), coronary heart disease, and inflammatory markers of vascular risk (e.g. C reactive protein) increase risk of MCI and MCI progression among participants in a longitudinal populationbased cohort. The study will be conducted at the Mayo Clinic Abigail van Buren Alzheimer's Disease Research Clinic. The K01 award will culminate in an R01 application that will pave the way for the candidate to become an independent investigator in MCI and AD research. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01AG028573-03
Application #
7455854
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Hsiao, John
Project Start
2006-09-30
Project End
2010-06-30
Budget Start
2008-07-01
Budget End
2010-06-30
Support Year
3
Fiscal Year
2008
Total Cost
$120,104
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Krell-Roesch, Janina; Lowe, Val J; Neureiter, Jennifer et al. (2018) Depressive and anxiety symptoms and cortical amyloid deposition among cognitively normal elderly persons: the Mayo Clinic Study of Aging. Int Psychogeriatr 30:245-251
Krell-Roesch, Janina; Feder, Nathanael T; Roberts, Rosebud O et al. (2018) Leisure-Time Physical Activity and the Risk of Incident Dementia: The Mayo Clinic Study of Aging. J Alzheimers Dis 63:149-155
Roberts, Rosebud O; Kang, Yoo Na; Hu, Chunling et al. (2017) Decreased Expression of Sulfatase 2 in the Brains of Alzheimer's Disease Patients: Implications for Regulation of Neuronal Cell Signaling. J Alzheimers Dis Rep 1:115-124
Pink, Anna; Przybelski, Scott A; Krell-Roesch, Janina et al. (2017) Cortical Thickness and Anxiety Symptoms Among Cognitively Normal Elderly Persons: The Mayo Clinic Study of Aging. J Neuropsychiatry Clin Neurosci 29:60-66
Pink, Anna; Przybelski, Scott A; Krell-Roesch, Janina et al. (2017) Cortical Thickness and Depressive Symptoms in Cognitively Normal Individuals: The Mayo Clinic Study of Aging. J Alzheimers Dis 58:1273-1281
Vassilaki, Maria; Christianson, Teresa J; Mielke, Michelle M et al. (2017) Neuroimaging biomarkers and impaired olfaction in cognitively normal individuals. Ann Neurol 81:871-882
Krell-Roesch, Janina; Vemuri, Prashanthi; Pink, Anna et al. (2017) Association Between Mentally Stimulating Activities in Late Life and the Outcome of Incident Mild Cognitive Impairment, With an Analysis of the APOE ?4 Genotype. JAMA Neurol 74:332-338
Krell-Roesch, Janina; Pink, Anna; Roberts, Rosebud O et al. (2016) Timing of Physical Activity, Apolipoprotein E ?4 Genotype, and Risk of Incident Mild Cognitive Impairment. J Am Geriatr Soc 64:2479-2486
Sprung, Juraj; Roberts, Rosebud O; Knopman, David S et al. (2016) Perioperative Delirium and Mild Cognitive Impairment. Mayo Clin Proc 91:273-4
Krell-Roesch, Janina; Ruider, Hanna; Lowe, Val J et al. (2016) FDG-PET and Neuropsychiatric Symptoms among Cognitively Normal Elderly Persons: The Mayo Clinic Study of Aging. J Alzheimers Dis 53:1609-16

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