). The HIV Care Continuum is a compelling epidemiologic framework describing the movement of people living with HIV/AIDS through care, including diagnosis, linkage and retention in care, use of antiretroviral therapy (ART), and ultimately, viral suppression. Health policies may profoundly influence outcomes along the Care Continuum, and these effects may be modified across regions and through individual contexts. In observational cohorts, retention in clinical care, ART use, and viral suppression proportions have varied depending on available data and the population under study. The US National HIV/AIDS Strategy (updated to 2020) and the revised 2013 World Health Organization ART guidelines also reference milestones in the Care Continuum. Because the Patient Protection and Affordable Care Act (ACA) and other national health policies in North and Latin American countries aim to improve healthcare access and reduce health disparities, describing the effect of policy and contextual factors on Care Continuum outcomes in these settings is of great interest to epidemiologists, clinicians, and policy makers. This research seeks to quantify health policy, sociodemographic, contextual, and geographic patterns and correlates of HIV Care Continuum outcomes among HIV-infected persons in the United States (US), Canada, and Mexico. Contextual factors include psychiatric illness, regional poverty, residential urbanicity, and other individual and environmental characteristics. The North American AIDS Cohort Collaboration on Research and Design (NA- ACCORD) and Caribbean, Central and South America network for HIV epidemiology (CCASAnet) provide rich data sources in which to conduct this work.
Aim 1 will quantify disparities in Care Continuum outcomes in North and Latin America, assessing health system, demographic, risk, contextual, and geographic differences. Because research into the influence of contextual factors and health system characteristics on Care Continuum outcomes in longitudinal cohorts with clinical care data have been sparse or geographically limited, this analysis will be novel and of significant importance.
Aims 2 and 3 will provide inferences about the ACA's effects on improving healthcare among HIV-infected individuals in care in the US. The state-led expansion of Medicaid coverage under the ACA will be used as a quasi-experiment to assess effects on Care Continuum and other HIV disease outcomes, comparing pre-ACA (pre-2014) to ACA implementation periods.

Public Health Relevance

). HIV remains a massive public health challenge both domestically and internationally; the HIV Care Continuum is a widely used and powerful epidemiologic framework applicable to those suffering from HIV, and the influence of public health and health system policies across the Continuum may be profound. By assessing the dynamic process of the HIV Care Continuum in discrete stages, and examining disparities by health policy, geography, and individual context, transitions that demand improvement and specific targets for public health and clinical interventions can more easily be identified. The US National HIV/AIDS Strategy (updated to 2020) and revised 2013 World Health Organization ART guidelines also reference milestones in the Care Continuum; because the Patient Protection and Affordable Care Act (ACA) and other national health policies implemented in North and Latin American countries aim to improve healthcare access and reduce health disparities in accord with these milestones, describing the effect of policy and individual contextual factors on Care Continuum outcomes, as this study aims to do, will be of great interest and utility to epidemiologists, clinicians, and policy makers.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01AI131895-03
Application #
9709211
Study Section
Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
Program Officer
Mckaig, Rosemary G
Project Start
2017-07-05
Project End
2022-06-30
Budget Start
2019-07-01
Budget End
2020-06-30
Support Year
3
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
079917897
City
Nashville
State
TN
Country
United States
Zip Code
37232
Rebeiro, Peter F; McPherson, Tristan D; Goggins, Kathryn M et al. (2018) Health Literacy and Demographic Disparities in HIV Care Continuum Outcomes. AIDS Behav 22:2604-2614
Rebeiro, Peter F; Howe, Chanelle J; Rogers, William B et al. (2018) The relationship between adverse neighborhood socioeconomic context and HIV continuum of care outcomes in a diverse HIV clinic cohort in the Southern United States. AIDS Care 30:1426-1434
Wong, Cherise; Gange, Stephen J; Moore, Richard D et al. (2018) Multimorbidity Among Persons Living with Human Immunodeficiency Virus in the United States. Clin Infect Dis 66:1230-1238
Rickles, Michael; Rebeiro, Peter F; Sizemore, Lindsey et al. (2018) Tennessee's In-state Vulnerability Assessment for a ""Rapid Dissemination of Human Immunodeficiency Virus or Hepatitis C Virus Infection"" Event Utilizing Data About the Opioid Epidemic. Clin Infect Dis 66:1722-1732
McGoy, Shanell L; Pettit, April C; Morrison, Melissa et al. (2018) Use of Social Network Strategy Among Young Black Men Who Have Sex With Men for HIV Testing, Linkage to Care, and Reengagement in Care, Tennessee, 2013-2016. Public Health Rep 133:43S-51S
De Boni, Raquel B; Peratikos, Meridith B; Shepherd, Bryan E et al. (2018) Is substance use associated with HIV cascade outcomes in Latin America? PLoS One 13:e0194228
Spires, Steven S; Rebeiro, Peter F; Miller, Mickie et al. (2018) Medically Attended Catheter Complications Are Common in Patients With Outpatient Central Venous Catheters. Infect Control Hosp Epidemiol 39:439-444
Wolff, Marcelo J; Cortes, Claudia P; Mejìa, Fernando A et al. (2018) Evaluating the care cascade after antiretroviral therapy initiation in Latin America. Int J STD AIDS 29:4-12
Imdad, Aamer; Retzer, Fiona; Thomas, Linda S et al. (2018) Impact of Culture-Independent Diagnostic Testing on Recovery of Enteric Bacterial Infections. Clin Infect Dis 66:1892-1898
Rebeiro, Peter Francis; Ivey, Kelsey Sunderland; Craig, Kaylin Smith et al. (2017) New Faces of HIV Infection: Age, Race, and Timing of Entry into HIV Care in the Southeastern United States. J Int Assoc Provid AIDS Care 16:347-352

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