This application for a Mentored Research Scientist Development Award (K01) seeks support for development of a unique program of interdisciplinary independent research that combines social theories and research methods of social organization with that of infectious disease dynamics to study ways in which the social organization of communities may simultaneously impact access to social resources and transmission of infectious diseases including HIV. The K01 will support structured training, coursework, tutorials, intensive mentored relationships, and empirical research within a rigorous interdisciplinary institutional environment. Specific training objectives are to obtain: 1) expertie in sociometric network concepts, methods, and measures; 2) skills in phylogenetic analysis and infectious disease dynamics theories; and 3) expertise in the study of social organization and social capital; and to: 4) integrate new skills and concepts with current research to inform intervention development and seek funding as an independent scientist. The proposed training and research is a natural next career step that builds upon a background of social, behavioral, and epidemiological HIV and substance use research and is responsive to identified priorities for U.S. HIV prevention. The disproportionate and severe HIV epidemic among African-American men who have sex with men (AAMSM) requires an understanding of community social dynamics in order to advance development of interventions that integrate behavioral, structural, and biomedical components. A long-term goal is to understand how the social organization of AAMSM communities, their socio-economic stability, and their HIV transmission dynamics are interrelated to inform innovative HIV prevention and care interventions. The objective of this research is to examine HIV transmission pathways and access to social capital within AAMSM social and affiliation networks and establish a methodological, theoretical, and operational foundation for future research. Research specific aims are to: 1) evaluate HIV phylogenetic clustering and identify characteristics of persons in clusters with AAMSM; 2) determine presence and correlates of network social capital among AAMSM; and 3) characterize AAMSM affiliations with formal organizations and social settings and identify affiliation network influences on HIV and substance use. These hypotheses will be tested through examination of HIV genetic sequence data collected among approximately 2000 HIV-positive individuals in Maryland between 2012-2015, including an anticipated 38% AAMSM, and primary data collection with 300 adult AAMSM in Baltimore, Maryland. Findings will inform the approach and conceptual framework and provide skills for a broader R01 study examining pathways between social structures and HIV transmission. The research and training from the award will result in scientific publications that will provide insight into social and structural influences on HIV transmission among AAMSM and provide direction for intervention development.

Public Health Relevance

The proposed training will prepare the applicant to study how the social organization of communities influences access to social resources and HIV transmission potential. The proposed research will: 1) provide a foundation for innovative biobehavioral examinations of HIV transmission within community networks; and 2) inform development, implementation, and evaluation of bio-behavioral, social, and structural HIV intervention strategies.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01DA041259-03
Application #
9471805
Study Section
Behavioral and Social Science Approaches to Preventing HIV/AIDS Study Section (BSPH)
Program Officer
Schulden, Jeffrey D
Project Start
2016-05-01
Project End
2021-04-30
Budget Start
2018-05-01
Budget End
2019-04-30
Support Year
3
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21205
Schlusser, Katherine E; Sharma, Shweta; de la Torre, Pola et al. (2018) Comparison of Self-report to Biomarkers of Recent HIV Infection: Findings from the START Trial. AIDS Behav 22:2277-2283
Sherman, Susan G; Hast, Marisa; Park, Ju Nyeong et al. (2018) Correlates of exchange sex among a population-based sample of low-income women who have heterosexual sex in Baltimore. AIDS Care 30:1273-1281
Ransome, Yusuf; Thurber, Katherine A; Swen, Melody et al. (2018) Social capital and HIV/AIDS in the United States: Knowledge, gaps, and future directions. SSM Popul Health 5:73-85
Friedman, Samuel R; Williams, Leslie; Young, April M et al. (2018) Network Research Experiences in New York and Eastern Europe: Lessons for the Southern US in Understanding HIV Transmission Dynamics. Curr HIV/AIDS Rep 15:283-292
Rose, Rebecca; Lamers, Susanna L; Dollar, James J et al. (2017) Identifying Transmission Clusters with Cluster Picker and HIV-TRACE. AIDS Res Hum Retroviruses 33:211-218
German, Danielle; Grabowski, Mary Kate; Beyrer, Chris (2017) Enhanced use of phylogenetic data to inform public health approaches to HIV among men who have sex with men. Sex Health 14:89-96
German, Danielle; Brady, Kathleen; Kuo, Irene et al. (2017) Characteristics of Black Men Who Have Sex With Men in Baltimore, Philadelphia, and Washington, D.C.: Geographic Diversity in Socio-Demographics and HIV Transmission Risk. J Acquir Immune Defic Syndr 75 Suppl 3:S296-S308