Currently, more than a dozen genomes have been sequenced from diverse organisms, with additions anticipated almost weekly. At the same time, the database of known protein folds is increasing at a steady rate. The overall goal of this project is to study fold patterns and their relation to primary sequence data. In particular, we seek a. formal hierarchical description of protein folds that lends itself to automatic fold classification and to prediction of novel, theoretically feasible folds that have yet to be found experimentally. To achieve this goal, we intend to analyze the relation between known structures and to develop a theory of folds. An important component of this proposal includes a course of study in molecular biology, to assure that problems are framed in a realistic manner and proposed solutions are useful. Proteins are essential components in all biological processes, and, as such, their behavior and inter-relationships underwrite our understanding of all biological processes, in both health and disease.

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
1K01HG000031-01A1
Application #
6087686
Study Section
Ethical, Legal, Social Implications Review Committee (GNOM)
Program Officer
Felsenfeld, Adam
Project Start
2000-09-01
Project End
2003-08-31
Budget Start
2000-09-01
Budget End
2001-08-31
Support Year
1
Fiscal Year
2000
Total Cost
$80,649
Indirect Cost
Name
Johns Hopkins University
Department
Physiology
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218