The aim of the study is to relate the clinical phenomenology of schizophrenia to disorders of brain structure and function. The research is based on the postulate that the symptoms and behavior observed in schizophrenic disorders have anatomical and physiological substrates and, consequently, that our understanding of schizophrenia is linked to the unraveling of brain-behavior links. As a result of recent advances in brain imaging techniques, which have broadened and enriched the neurological data base of schizophrenia, hypotheses regarding brain anomalies in schizophrenia and their relationship to clinical phenomenology can now be more reliably and profitably explored. This study proposes to utilize evoked potential data using the new noninvasive neurophysiological topographic technique of brain electrical activity mapping and magnetic resonance imaging (MRI), together with computerized tomography (CT) to define brain structural and functional abnormalities in schizophrenics. These data will be compared to those from matched normal controls and affective disorder patients. Clinical symptom measures include: thought disorder, negative and positive symptoms, and clinical status measures such as age of onset, premorbid functioning, and severity and duration of illness. The correlations among anatomical, neurophysiological, and clinical measures will be determined in order to define which symptom/sign groupings occur together to further define subgroups within the schizophrenic syndrome, perhaps reflecting different pathologies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01MH000746-05
Application #
2239969
Study Section
Research Scientist Development Review Committee (MHK)
Project Start
1988-09-01
Project End
1993-08-31
Budget Start
1992-09-01
Budget End
1993-08-31
Support Year
5
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Harvard University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Niznikiewicz, Margaret A; Friedman, Michelle; Shenton, Martha E et al. (2004) Processing sentence context in women with schizotypal personality disorder: an ERP study. Psychophysiology 41:367-71
Niznikiewicz, Margaret A; Shenton, Martha E; Voglmaier, Martina et al. (2002) Semantic dysfunction in women with schizotypal personality disorder. Am J Psychiatry 159:1767-74
Kwon, J S; O'Donnell, B F; Wallenstein, G V et al. (1999) Gamma frequency-range abnormalities to auditory stimulation in schizophrenia. Arch Gen Psychiatry 56:1001-5
O'Donnell, B F; McCarley, R W; Potts, G F et al. (1999) Identification of neural circuits underlying P300 abnormalities in schizophrenia. Psychophysiology 36:388-98
Niznikiewicz, M A; Voglmaier, M; Shenton, M E et al. (1999) Electrophysiological correlates of language processing in schizotypal personality disorder. Am J Psychiatry 156:1052-8
Levitt, J J; Shenton, M E; McCarley, R W et al. (1994) Premorbid adjustment in schizophrenia: implications for psychosocial and ventricular pathology. Schizophr Res 12:159-68
Kikinis, R; Shenton, M E; Gerig, G et al. (1994) Temporal lobe sulco-gyral pattern anomalies in schizophrenia: an in vivo MR three-dimensional surface rendering study. Neurosci Lett 182:7-12
O'Donnell, B F; Hokama, H; McCarley, R W et al. (1994) Auditory ERPs to non-target stimuli in schizophrenia: relationship to probability, task-demands, and target ERPs. Int J Psychophysiol 17:219-31
Shenton, M E; O'Donnell, B F; Nestor, P G et al. (1993) Temporal lobe abnormalities in a patient with schizophrenia who has word-finding difficulty: use of high-resolution magnetic resonance imaging and auditory P300 event-related potentials. Harv Rev Psychiatry 1:110-7
Faux, S F; McCarley, R W; Nestor, P G et al. (1993) P300 topographic asymmetries are present in unmedicated schizophrenics. Electroencephalogr Clin Neurophysiol 88:32-41

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