This proposal focuses on our efforts to understand molecular mechanisms regulating memory formation. It has been previously shown that cAMP response element binding protein (CREB)-mediated transcription is required in long-term plasticity and this phenomenon is conserved from mollusks to mammals although the presence of multiple CREB forms in mammals complicates interpretation of results obtained from study of CREB mutant mice. The proposed research will involve study of transcription- dependent synaptic plasticity which underlies learning and memory processes. The generated mutant mice will allow for genetic control of CREB-dependent gene expression in hippocampal neurons, and study the molecular and cellular mechanisms of the transition from short- to long-term memory. Mutant mice will be challenged in several learning and memory paradigms which are known to be dependent on the integrity of hippocampus. A newly created mouse model will provide the unique approach to study memory consolidation at molecular, cellular and cognitive level.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01MH001785-04
Application #
6629179
Study Section
Special Emphasis Panel (ZRG1-IFCN-7 (01))
Program Officer
Wynne, Debra K
Project Start
2000-02-10
Project End
2004-01-31
Budget Start
2003-02-01
Budget End
2004-01-31
Support Year
4
Fiscal Year
2003
Total Cost
$114,653
Indirect Cost
Name
University of California San Diego
Department
Neurosciences
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Korzus, Edward; Rosenfeld, Michael G; Mayford, Mark (2004) CBP histone acetyltransferase activity is a critical component of memory consolidation. Neuron 42:961-72