Abstract

This K02 competitive continuation application proposes to advance understanding of adolescent alcohol use disorders (AUDs) through examination of adult outcomes with innovative statistical techniques for longitudinal data. In Years 6 through 10, the program focus evolves from statistical techniques for categorical variables to techniques based on finite mixture models. The programmatic focus shifts from relationships among adolescent characteristics to adult outcomes. The project will emphasize person-centered statistical strategies to predict adult outcomes among adolescents characterized by substance involvement trajectories, psychopathology latent classes, childhood maltreatment histories, and treatment participation. With NIAAA and NIDA support, the Pittsburgh Adolescent Alcohol Research Center (PAARC) is completing adult follow-up assessments in adolescents with AUDs and a reference group. The hypotheses consider the confluence of behavioral, cognitive, and affective dysregulation in predicting AUD course, complications, and outcomes. Adult outcomes examined include AUDs, other substance use disorders, psychopathology,) personality disorders, academic achievement, work performance, family status, somatic symptoms, liver injury, and sexually transmitted diseases. Complementary data from the Center for Education and Drug Abuse Research (NIDA P50: PI Tarter, Co-PI Clark), a study of children at risk for alcohol and drug use disorders followed through adolescence into adulthood, will also be utilized. Incorporating categorical variables pertinent to symptom and diagnostic categories, the statistical strategies applied will include multivariate survival analysis, general growth mixture models, and Bayesian instance-based machine learning. These methods will be specifically optimized to construct clinically relevant models applicable to individual patients, serving as the basis for more thorough phenotype description, more effective prevention programs, and individually tailored treatment interventions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02AA000291-10
Application #
7481099
Study Section
Health Services Research Review Subcommittee (AA)
Program Officer
Shirley, Mariela
Project Start
1999-09-01
Project End
2010-02-28
Budget Start
2008-09-01
Budget End
2010-02-28
Support Year
10
Fiscal Year
2008
Total Cost
$143,320
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Clark, Duncan B; Martin, Christopher S; Chung, Tammy et al. (2016) Screening for Underage Drinking and Diagnostic and Statistical Manual of Mental Disorders, 5th Edition Alcohol Use Disorder in Rural Primary Care Practice. J Pediatr 173:214-20
Cornelius, Jack R; Kirisci, Levent; Reynolds, Maureen et al. (2015) Does the Transmissible Liability Index (TLI) assessed in late childhood predict suicidal symptoms at young adulthood? Am J Drug Alcohol Abuse 41:264-8
Cornelius, Jack; Kirisci, Levent; Reynolds, Maureen et al. (2014) Does stress mediate the development of substance use disorders among youth transitioning to young adulthood? Am J Drug Alcohol Abuse 40:225-9
Cornelius, Jack R; Haas, Gretchen L; Goldstein, Gerald et al. (2014) The ""S"" Allele of the Serotonin Transporter Is Not Associated with Major Depression in a Sample OF Veterans. Adv Genet Res 12:1-10
Thatcher, Dawn L; Pajtek, Stefan; Tarter, Ralph et al. (2014) Amygdala Activation and Emotional Processing in Adolescents at Risk for Substance Use Disorders. J Child Adolesc Subst Abuse 23:200-204
Clark, D B; Chung, T; Pajtek, S et al. (2013) Neuroimaging methods for adolescent substance use disorder prevention science. Prev Sci 14:300-9
Cornelius, Jack R; Douaihy, Antoine B; Clark, Duncan B et al. (2013) Mirtazapine in Comorbid Major Depression and Alcohol Use Disorder: A Long-Term Follow-Up Study. J Addict Behav Ther Rehabil 3:
Cornelius, Jack R; Aizenstein, Howard J; Chung, Tammy A et al. (2013) Paradoxical Decrease in Striatal Activation on an fMRI Reward Task Following Treatment in Youth with Co-morbid Cannabis Dependence/Major Depression. Adv Psychol Res 93:123-130
Cornelius, Jack R; Kirisci, Levent (2013) Assessing TLI as a Predictor of Treatment Seeking for SUD among Youth Transitioning to Young Adulthood. Adv Psychol Res 98:85-94
Cornelius, Jack R; Douaihy, Antoine B; Kirisci, Levent et al. (2013) LONGER-TERM EFFECTIVENESS OF CBT IN TREATMENT OF COMORBID AUD/MDD ADOLESCENTS. Int J Med Biol Front 19:

Showing the most recent 10 out of 72 publications