Abstract

This application is a renewal of my K02 award, which had the stated goal of developing an interdisciplinary program of research aimed at advancing our understanding of how genetic influences impact the development of alcohol use disorders by integrating findings across twin studies, gene identification projects, and longitudinal, community-based samples. Over the past four years of the project, with the protected research time afforded by my K award, I have published >70 peer-reviewed papers and obtained three new R01s, while continuing my role as PI/site PI on four additional existing grants. In the renewal of my K02, I propose to expand my program of research to incorporate prevention/intervention studies in order to actualize on the

Public Health Relevance

The complexity of the genetics of alcohol dependence necessitates an interdisciplinary perspective; too often research in different areas is conducted in isolation. By integrating twin studies, gene identification projects, community-based samples, and prevention/intervention projects, we can characterize developmental pathways of risk by which genetic and environmental influences contribute to alcohol use disorders, and importantly, use that information to develop more effective, tailored programs of prevention and intervention.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02AA018755-10
Application #
9762758
Study Section
National Institute on Alcohol Abuse and Alcoholism Initial Review Group (AA)
Program Officer
Parsian, Abbas
Project Start
2010-02-01
Project End
2020-08-31
Budget Start
2019-09-01
Budget End
2020-08-31
Support Year
10
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
Virginia Commonwealth University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
105300446
City
Richmond
State
VA
Country
United States
Zip Code
23298

  Publications

Savage, Jeanne E; Rose, Richard J; Pulkkinen, Lea et al. (2018) Early maturation and substance use across adolescence and young adulthood: A longitudinal study of Finnish twins. Dev Psychopathol 30:79-92
Tubbs, Justin D; Savage, Jeanne E; Adkins, Amy E et al. (2018) Mindfulness moderates the relation between trauma and anxiety symptoms in college students. J Am Coll Health :1-11
Do, Elizabeth K; Prom-Wormley, Elizabeth C; Fuemmeler, Bernard F et al. (2018) Associations Between Initial Subjective Experiences with Tobacco and Self-Reported Recent Use in Young Adulthood. Subst Use Misuse 53:2291-2298
Neale, Zoe E; Salvatore, Jessica E; Cooke, Megan E et al. (2018) The Utility of a Brief Web-Based Prevention Intervention as a Universal Approach for Risky Alcohol Use in College Students: Evidence of Moderation by Family History. Front Psychol 9:747
Savage, Jeanne E; Salvatore, Jessica E; Aliev, Fazil et al. (2018) Polygenic Risk Score Prediction of Alcohol Dependence Symptoms Across Population-Based and Clinically Ascertained Samples. Alcohol Clin Exp Res 42:520-530
Bourdon, Jessica L; Moore, Ashlee A; Long, Elizabeth C et al. (2018) The relationship between on-campus service utilization and common mental health concerns in undergraduate college students. Psychol Serv :
van der Vaart, Andrew; Meng, Xianfang; Bowers, M Scott et al. (2018) Glycogen synthase kinase 3 beta regulates ethanol consumption and is a risk factor for alcohol dependence. Neuropsychopharmacology 43:2521-2531
Barr, Peter B; Silberg, Judy; Dick, Danielle M et al. (2018) Childhood socioeconomic status and longitudinal patterns of alcohol problems: Variation across etiological pathways in genetic risk. Soc Sci Med 209:51-58
Dick, Danielle M (2018) Commentary for Special Issue of Prevention Science ""Using Genetics in Prevention: Science Fiction or Science Fact?"" Prev Sci 19:101-108
Su, Jinni; Kuo, Sally I-Chun; Meyers, Jacquelyn L et al. (2018) Examining interactions between genetic risk for alcohol problems, peer deviance, and interpersonal traumatic events on trajectories of alcohol use disorder symptoms among African American college students. Dev Psychopathol 30:1749-1761

Showing the most recent 10 out of 181 publications