Abstract

This application is a renewal of my K02 award, which had the stated goal of developing an interdisciplinary program of research aimed at advancing our understanding of how genetic influences impact the development of alcohol use disorders by integrating findings across twin studies, gene identification projects, and longitudinal, community-based samples. Over the past four years of the project, with the protected research time afforded by my K award, I have published >70 peer-reviewed papers and obtained three new R01s, while continuing my role as PI/site PI on four additional existing grants. In the renewal of my K02, I propose to expand my program of research to incorporate prevention/intervention studies in order to actualize on the

Public Health Relevance

The complexity of the genetics of alcohol dependence necessitates an interdisciplinary perspective; too often research in different areas is conducted in isolation. By integrating twin studies, gene identification projects, community-based samples, and prevention/intervention projects, we can characterize developmental pathways of risk by which genetic and environmental influences contribute to alcohol use disorders, and importantly, use that information to develop more effective, tailored programs of prevention and intervention.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02AA018755-10
Application #
9762758
Study Section
National Institute on Alcohol Abuse and Alcoholism Initial Review Group (AA)
Program Officer
Parsian, Abbas
Project Start
2010-02-01
Project End
2020-08-31
Budget Start
2019-09-01
Budget End
2020-08-31
Support Year
10
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
Virginia Commonwealth University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
105300446
City
Richmond
State
VA
Country
United States
Zip Code
23298

  Publications

van der Vaart, Andrew; Meng, Xianfang; Bowers, M Scott et al. (2018) Glycogen synthase kinase 3 beta regulates ethanol consumption and is a risk factor for alcohol dependence. Neuropsychopharmacology 43:2521-2531
Barr, Peter B; Silberg, Judy; Dick, Danielle M et al. (2018) Childhood socioeconomic status and longitudinal patterns of alcohol problems: Variation across etiological pathways in genetic risk. Soc Sci Med 209:51-58
Dick, Danielle M (2018) Commentary for Special Issue of Prevention Science ""Using Genetics in Prevention: Science Fiction or Science Fact?"" Prev Sci 19:101-108
Su, Jinni; Kuo, Sally I-Chun; Meyers, Jacquelyn L et al. (2018) Examining interactions between genetic risk for alcohol problems, peer deviance, and interpersonal traumatic events on trajectories of alcohol use disorder symptoms among African American college students. Dev Psychopathol 30:1749-1761
Su, Jinni; Hancock, Linda; Wattenmaker McGann, Amanda et al. (2018) Evaluating the effect of a campus-wide social norms marketing intervention on alcohol-use perceptions, consumption, and blackouts. J Am Coll Health 66:219-224
Cusack, Shannon E; Hicks, Terrell A; Bourdon, Jessica et al. (2018) Prevalence and predictors of PTSD among a college sample. J Am Coll Health :1-9
Su, Jinni; Kuo, Sally I-Chun; Bucholz, Kathleen K et al. (2018) Understanding Mechanisms of Genetic Risk for Adolescent Internalizing and Externalizing Problems: The Mediating Role of Parenting and Personality. Twin Res Hum Genet 21:310-321
Aliev, Fazil; Salvatore, Jessica E; Agrawal, Arpana et al. (2018) A Brief Critique of the TATES Procedure. Behav Genet 48:155-167
Docherty, Anna R; Moscati, Arden; Dick, Danielle et al. (2018) Polygenic prediction of the phenome, across ancestry, in emerging adulthood. Psychol Med 48:1814-1823
Su, Jinni; Kuo, Sally I-Chun; Aliev, Fazil et al. (2018) Influence of Parental Alcohol Dependence Symptoms and Parenting on Adolescent Risky Drinking and Conduct Problems: A Family Systems Perspective. Alcohol Clin Exp Res 42:1783-1794

Showing the most recent 10 out of 181 publications