This project is designed to assess psychiatric disorders and addictive behaviors in the first degree relatives of a sample of opiate addicts and to evaluate the applicability of genetic and non-genetic models as explanations for the patterns of disorders observed in the addicts' families. The design follows in part from our previous work with opiate addicts which indicates that this population is heterogenous for psychiatric disorders, with secondary depression and antisocial personality being the most commonly diagnosed conditions. In this study, three groups of addicted probands will be evaluated: addicts with no additional diagnosis, addicts with secondary depression, and addicts with antisocial personality. First degree relatives of probands will be evaluated for addictive behaviors, substance use patterns, psychiatric disorders, and personality characteristics. In addition, aspects of family functioning such as separation or divorce of parents, excessive closeness, and crossed ethnicity of parents will also be assessed. Rates of psychiatric disorders in the surrounding community and comparable data on the first degree relatives of depressives and normals are availabel from previously completed research for comparison to findings with opiate addicts. Data analysis will be carried out to evaluate several types of issues. An epidemiological analysis will assess relative risk of addicts' family members for psychiatric disorders in comparison to community rates. Other analyses will assess the extent to which observed patterns of addictive behaviors in addicts' families are compatible with various genetic models for transmission of the trait and the extent to which the findings are compatible with hypotheses regarding nongenetic familial factors in opiate addiction.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02DA000089-03
Application #
3069414
Study Section
(DACA)
Project Start
1983-03-01
Project End
1988-02-29
Budget Start
1985-03-01
Budget End
1986-02-28
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Yale University
Department
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
Babor, T F; Hofmann, M; DelBoca, F K et al. (1992) Types of alcoholics, I. Evidence for an empirically derived typology based on indicators of vulnerability and severity. Arch Gen Psychiatry 49:599-608
Kosten, T R; Rounsaville, B J (1988) Suicidality among opioid addicts: 2.5 year follow-up. Am J Drug Alcohol Abuse 14:357-69
Kosten, T; Rounsaville, B; Kleber, H (1988) A 2.5 year follow-up of abstinence and relapse to cocaine abuse in opioid addicts. NIDA Res Monogr 81:231-6
Kosten, T R; Rounsaville, B J; Kleber, H D (1988) Antecedents and consequences of cocaine abuse among opioid addicts. A 2.5-year follow-up. J Nerv Ment Dis 176:176-81
Kosten, T R; Rounsaville, B J; Kleber, H D (1987) Multidimensionality and prediction of treatment outcome in opioid addicts: 2.5-year follow-up. Compr Psychiatry 28:3-13
Kosten, T R; Rounsaville, B J (1987) Source of income as a predictor in opioid addicts: 2.5 year follow-up. NIDA Res Monogr 76:196-9
Kosten, T R; Rounsaville, B J; Babor, T F et al. (1987) The dependence syndrome across different psychoactive substances: revised DSM-III. NIDA Res Monogr 76:255-8
Rounsaville, B J; Chevron, E S; Prusoff, B A et al. (1987) The relation between specific and general dimensions of the psychotherapy process in interpersonal psychotherapy of depression. J Consult Clin Psychol 55:379-84
Kosten, T R; Rounsaville, B J; Kleber, H D (1987) Predictors of 2.5-year outcome in opioid addicts: pretreatment source of income. Am J Drug Alcohol Abuse 13:19-32
Rounsaville, B J; Kosten, T R; Kleber, H D (1987) The antecedents and benefits of achieving abstinence in opioid addicts: a 2.5-year follow-up study. Am J Drug Alcohol Abuse 13:213-29

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