The progress during the past four years and future plans are: 1) Longitudinal: This component has focused on a 25-year follow-up of the then large-scale epidemiologic study (""""""""Vietnam Drug User Returns"""""""") conducted in the early 1970's. The main follow-up data collection has been completed after decades of hiatus, with continued fundings starting to complete database archiving, data analyses, and dissemination (""""""""Washington University Vietnam Era Study Phase III (VES-III),"""""""" R01DA09379, R01DA09281). The future plans are to: 1a) complete data analyses and main publications from VES-III; 1b) conduct a followback investigation on the decreased extent of bias inherent in such censored data; 1c) plan and conduct small-scale studies related to intervention for selected high-risk subgroups of the VES-III cohort; and 1d) begin preparation for an offspring study of the VES-III cohort. 2) Cross-Cultural/International: This component centers on the notion of cross-culturally unique protective factors and their moderating effects. The first phase which aims at replicating a developmental psycho pathology model substantiated in the western literature, using an existing large database from five countries (""""""""Cross-Cultural Epidemiology-Phase I (CC-I),"""""""" R01DK10021), is currently in the second year of funding. Future plans are to: 2a) complete data analyses and main publications for CC-I; 2b) plan and begin implementing a study to examine adolescent substance use and mental health among the Japanese and Vietnamese, focusing on protective factors and their decay process, using an embedded cohort-sequential, migration design (""""""""Pacific Rim"""""""" Project); 2c) implement a feasibility study to conduct substance abuse and psychiatric interviews and collect DNA from Japanese adolescents to study gene-environment interaction effects rising from the presence of ethnic-specific alcohol sensitivity genes and their consequences to other drug use (""""""""Flushing Syndrome,"""""""" P50AA11998, Pilot 3); 2d) explore potentials for collecting DNA from the Pacific Rim Study cohorts to incorporate genetic immunity to use of alcohol and potentially other psychoactive substances to the understanding of environmental moderators; 2e) explore potentials for future comparative analyses of the data on the Vietnamese adolescent against trauma and its relation to substance abuse (""""""""Crossroad"""""""" Study). In the next five years, the P.I. plans to: reach closure to VES-III (1a), the followback extension (1b), CC-I (2a), and the Flushing Syndrome feasibility (2c); implement VES-III intervention (1c) and the Pacific Rim Project (2b); begins preparatory work for the remaining (1d, 2d, 2e). 3) Methodological Enhancement component continues previous attempts to integrate novel technologies to more traditional statistical methods to improve epidemiologic prediction and explanatory precision.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Development Award - Research (K02)
Project #
2K02DA000221-06
Application #
2902234
Study Section
Special Emphasis Panel (ZDA1-MXS-M (20))
Program Officer
Conway, Kevin P
Project Start
1994-09-30
Project End
2004-08-31
Budget Start
1999-09-01
Budget End
2000-08-31
Support Year
6
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Washington University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Balan, Sundari; Widner, Greg; Shroff, Manan et al. (2013) Drug use disorders and post-traumatic stress disorder over 25 adult years: role of psychopathology in relational networks. Drug Alcohol Depend 133:228-34
Sakai, Joseph T; Wang, Cynthia; Price, Rumi Kato (2010) Substance use and dependence among Native Hawaiians, Other Pacific Islanders, and Asian ethnic groups in the United States: contrasting multiple-race and single-race prevalence rates from a national survey. J Ethn Subst Abuse 9:173-85
Sakai, J T; Risk, N K; Tanaka, C A et al. (2008) Conduct disorder among Asians and Native Hawaiian/Pacific Islanders in the USA. Psychol Med 38:1013-25
Ledgerwood, David M; Goldberger, Bruce A; Risk, Nathan K et al. (2008) Comparison between self-report and hair analysis of illicit drug use in a community sample of middle-aged men. Addict Behav 33:1131-9
Sakai, Joseph T; Ho, P Michael; Shore, Jay H et al. (2005) Asians in the United States: substance dependence and use of substance-dependence treatment. J Subst Abuse Treat 29:75-84
Price, Rumi Kato; Risk, Nathan K; Haden, Ashley H et al. (2004) Post-traumatic stress disorder, drug dependence, and suicidality among male Vietnam veterans with a history of heavy drug use. Drug Alcohol Depend 76 Suppl:S31-43
Price, R K; Risk, N K; Spitznagel, E L (2001) Remission from drug abuse over a 25-year period: patterns of remission and treatment use. Am J Public Health 91:1107-13
Price, R K; Risk, N K; Murray, K S et al. (2001) Twenty-five year mortality of US servicemen deployed in Vietnam: predictive utility of early drug use. Drug Alcohol Depend 64:309-18
Price, R K; Spitznagel, E L; Downey, T J et al. (2000) Applying artificial neural network models to clinical decision making. Psychol Assess 12:40-51