The overall aim of this proposal is to support the continuing development of the applicant as a scientist in the field of drug abuse treatment. The applicant's program of research is driven by two main themes: 1) That pharmacotherapies may be developed by considering the heterogeneity of drug addicted samples and targeting interventions to specific subgroups; and 2) That the efficacy of medications may be enhanced by developing combined behavioral and pharmacologic interventions and by examining the implications of initial abstinence during a placebo lead-in upon medication effects. During the proposed K02, the applicant will serve as principle investigator on four main projects: I.) A placebo-controlled trial of venlafaxine for cocaine abusers with depressive disorders (P50 DA09236, Project 3); II.) A Stage I project to develop a behavioral therapy for depression in opiate dependent patients based on operant theory (R01 DA13118); III.) Cocaine medication development trials examining the efficacy of the NMDA antagonist memantine and the GABA enhancer gabapentin, and also examining the impact of abstinence during an initial placebo lead-in upon demonstration of medication effects (P50 DA12761, Project 1); and IV.) A controlled trial testing the efficacy of a behavioral therapy designed to improve the success of oral naltrexone maintenance for opiate dependence, and simultaneously testing the efficacy of an initial injection of a long-acting depot naltrexone formulation in improving retention in naltrexone maintenance treatment (R01 DA10746). The applicant will continue to assume a leadership role in the Department in mentoring young investigators, including junior colleagues on the above projects and research fellows. These mentorships extend the applicant's main research themes, for example addressing the treatment implications of comorbid disorders other than depression (e.g. attention deficit disorder, impulsive aggression, pathological gambling) and seeking opportunities for early intervention in children and adolescents at high risk for drug abuse. The applicant will continue to pursue a training plan focused on methodology and statistics of clinical trials, behavioral interventions, and the responsible conduct of research.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02DA000288-07
Application #
6523244
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Czechowicz, Dorynne D
Project Start
1996-04-01
Project End
2006-07-31
Budget Start
2002-08-01
Budget End
2003-07-31
Support Year
7
Fiscal Year
2002
Total Cost
$122,472
Indirect Cost
Name
Columbia University (N.Y.)
Department
Psychiatry
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Brooks, Adam C; Comer, Sandra D; Sullivan, Maria A et al. (2010) Long-acting injectable versus oral naltrexone maintenance therapy with psychosocial intervention for heroin dependence: a quasi-experiment. J Clin Psychiatry 71:1371-8
Raby, Wilfrid Noel; Carpenter, Kenneth M; Rothenberg, Jami et al. (2009) Intermittent marijuana use is associated with improved retention in naltrexone treatment for opiate-dependence. Am J Addict 18:301-8
Aharonovich, Efrat; Amrhein, Paul C; Bisaga, Adam et al. (2008) Cognition, commitment language, and behavioral change among cocaine-dependent patients. Psychol Addict Behav 22:557-62
Blanco, Carlos; Olfson, Mark; Goodwin, Renee D et al. (2008) Generalizability of clinical trial results for major depression to community samples: results from the National Epidemiologic Survey on Alcohol and Related Conditions. J Clin Psychiatry 69:1276-80
Levin, Frances R; Bisaga, Adam; Raby, Wilfrid et al. (2008) Effects of major depressive disorder and attention-deficit/hyperactivity disorder on the outcome of treatment for cocaine dependence. J Subst Abuse Treat 34:80-9
Carpenter, Kenneth M; Smith, Jennifer L; Aharonovich, Efrat et al. (2008) Developing therapies for depression in drug dependence: results of a stage 1 therapy study. Am J Drug Alcohol Abuse 34:642-52
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Collins, Eric D; Horton, Terry; Reinke, Katherine et al. (2007) Using buprenorphine to facilitate entry into residential therapeutic community rehabilitation. J Subst Abuse Treat 32:167-75
Nunes, Edward V; Rounsaville, Bruce J (2006) Comorbidity of substance use with depression and other mental disorders: from Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) to DSM-V. Addiction 101 Suppl 1:89-96
Raby, Wilfrid Noel; Carpenter, Kenneth M; Aharonovich, Efrat et al. (2006) Temperament characteristics, as assessed by the tridimensional personality questionnaire, moderate the response to sertraline in depressed opiate-dependent methadone patients. Drug Alcohol Depend 81:283-92

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